globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1911922116
论文题名:
Rickettsia conorii O antigen is the target of bactericidal Weil-Felix antibodies
作者: Kim H.K.; Premaratna R.; Missiakas D.M.; Schneewind O.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2019
卷: 116, 期:39
起始页码: 19659
结束页码: 19664
语种: 英语
英文关键词: Lipopolysaccharide ; O antigen ; Polysaccharide synthesis operon ; Transposon mutagenesis ; Weil-Felix reaction
Scopus关键词: bacterium antibody ; lipopolysaccharide ; O antigen ; outer membrane protein ; polysaccharide ; unclassified drug ; Weil Felix antibody ; Article ; bacterial immunity ; bacterial strain ; bacterium isolation ; controlled study ; insertional mutagenesis ; nonhuman ; operon ; priority journal ; protein assembly ; Rickettsia conorii ; serology ; transposon mutagenesis ; wild type
英文摘要: Rickettsial diseases have long been diagnosed with serum antibodies cross-reactive against Proteus vulgaris (Weil-Felix reaction). Although Weil-Felix antibodies are associated with the development of immunity, their rickettsial target and contribution to disease pathogenesis are not established. Here, we developed a transposon for insertional mutagenesis of Rickettsia conorii, isolating variants defective for replication in cultured cells and in spotted fever pathogenesis. Mutations in the polysaccharide synthesis operon (pso) abolish lipopolysaccharide O-antigen synthesis and Weil-Felix serology and alter outer-membrane protein assembly. Unlike wild-type R. conorii, pso mutants cannot elicit bactericidal antibodies that bind O antigen. The pso operon is conserved among rickettsial pathogens, suggesting that bactericidal antibodies targeting O antigen may generate universal immunity that could be exploited to develop vaccines against rickettsial diseases. © 2019 National Academy of Sciences. All rights reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163529
Appears in Collections:气候变化与战略

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作者单位: Kim, H.K., Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, IL 60649, United States, Department of Microbiology, University of Chicago, Chicago, IL 60637, United States; Premaratna, R., Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, 11010, Sri Lanka; Missiakas, D.M., Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, IL 60649, United States, Department of Microbiology, University of Chicago, Chicago, IL 60637, United States; Schneewind, O., Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Lemont, IL 60649, United States, Department of Microbiology, University of Chicago, Chicago, IL 60637, United States

Recommended Citation:
Kim H.K.,Premaratna R.,Missiakas D.M.,et al. Rickettsia conorii O antigen is the target of bactericidal Weil-Felix antibodies[J]. Proceedings of the National Academy of Sciences of the United States of America,2019-01-01,116(39)
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