globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1909154116
论文题名:
Recognition with metallo cavitands
作者: Rahman F.-U.; Li Y.-S.; Petsalakis I.D.; Theodorakopoulos G.; Rebek J.; Jr.; Yu Y.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2019
卷: 116, 期:36
起始页码: 17648
结束页码: 17653
语种: 英语
英文关键词: Cavitands ; Metallo cavitand ; Molecular recognition ; Pd(II) stabilized cavitand ; Water-soluble containers
Scopus关键词: acid ; alcohol ; alkane derivative ; diol derivative ; hydroxyl group ; metal ; quinoxaline ; unclassified drug ; Article ; binding affinity ; carbon nuclear magnetic resonance ; chemical binding ; chemical structure ; comparative study ; complex formation ; conformation ; electrospray mass spectrometry ; molecular recognition ; priority journal ; proton nuclear magnetic resonance ; synthesis
英文摘要: We describe here the effects ofmetal complexation on themolecular recognition behavior of cavitands with quinoxaline walls. The nitrogen atoms of the quinoxalines are near the upper rim of the vase-like shape and treatment with Pd(II) gave 2:1 metal:cavitand derivatives. Characterization by 1H, 13C NMR spectroscopy, HR ESIMS, and computations showed that the metals bridged adjacent quinoxaline panels and gave cavitands with C2v symmetry. Both water-soluble and organic-soluble versions were prepared and their host/guest complexes with alkanes, alcohols, acids, and diols (up to C12) were studied by 1H NMR spectroscopy. Analysis of the binding behavior indicated that the metals rigidified the walls of the receptive vase conformation and enhanced the binding of hydrophobic and even water-soluble guests, compared to related cavitands reported previously. The results demonstrated that the conformational dynamics of the cavitand were slowed by the coordination of Pd(II) and stabilized the host's complexes. © 2019 National Academy of Sciences. All rights reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163539
Appears in Collections:气候变化与战略

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作者单位: Rahman, F.-U., Center for Supramolecular Chemistry and Catalysis, Shanghai University, Shanghai, 200444, China, Department of Chemistry, College of Science, Shanghai University, Shanghai, 200444, China; Li, Y.-S., Center for Supramolecular Chemistry and Catalysis, Shanghai University, Shanghai, 200444, China, Department of Chemistry, College of Science, Shanghai University, Shanghai, 200444, China; Petsalakis, I.D., Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, Athens, 11635, Greece; Theodorakopoulos, G., Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, Athens, 11635, Greece; Rebek, J., Jr., Center for Supramolecular Chemistry and Catalysis, Shanghai University, Shanghai, 200444, China, Department of Chemistry, College of Science, Shanghai University, Shanghai, 200444, China, Skaggs Institute for Chemical Biology, Scripps Research Institute, San Diego, CA 92037, United States, Department of Chemistry, Scripps Research Institute, San Diego, CA 92037, United States; Yu, Y., Center for Supramolecular Chemistry and Catalysis, Shanghai University, Shanghai, 200444, China, Department of Chemistry, College of Science, Shanghai University, Shanghai, 200444, China

Recommended Citation:
Rahman F.-U.,Li Y.-S.,Petsalakis I.D.,et al. Recognition with metallo cavitands[J]. Proceedings of the National Academy of Sciences of the United States of America,2019-01-01,116(36)
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