DOI: 10.1073/pnas.1815342116
论文题名: Modulation of tissue growth heterogeneity by responses to mechanical stress
作者: Fruleux A. ; Boudaoud A.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2019
卷: 116, 期: 6 起始页码: 1940
结束页码: 1945
语种: 英语
英文关键词: Active fluid
; Growth variability
; Mechanical signals
; Morphogenesis
; Robustness
Scopus关键词: buffer
; anisotropy
; Article
; biological model
; biosynthesis
; cell adhesion
; cell growth
; cell heterogeneity
; cell maturation
; cellular stress response
; cytoskeleton
; extracellular matrix
; mechanical stress
; plant development
; prediction
; priority journal
; tissue growth
; animal
; biological model
; biomechanics
; cell enlargement
; cell size
; cell wall
; morphogenesis
; organ size
; plant
; Animals
; Anisotropy
; Biomechanical Phenomena
; Cell Adhesion
; Cell Enlargement
; Cell Size
; Cell Wall
; Cytoskeleton
; Extracellular Matrix
; Models, Biological
; Morphogenesis
; Organ Size
; Plants
; Stress, Mechanical
英文摘要: Morphogenesis often yields organs with robust size and shapes, whereas cell growth and deformation feature significant spatiotemporal variability. Here, we investigate whether tissue responses to mechanical signals contribute to resolve this apparent paradox. We built a model of growing tissue made of fiber-like material, which may account for the cytoskeleton, polar cell-cell adhesion, or the extracellular matrix in animals and for the cell wall in plants. We considered the synthesis and remodeling of this material, as well as the modulation of synthesis by isotropic and anisotropic response to mechanical stress. Formally, our model describes an expanding, mechanoresponsive, nematic, and active fluid. We show that mechanical responses buffer localized perturbations, with two possible regimes-hyporesponsive and hyperresponsive-and the transition between the two corresponds to a minimum value of the relaxation time. Whereas robustness of shapes suggests that growth fluctuations are confined to small scales, our model yields growth fluctuations that have long-range correlations. This indicates that growth fluctuations are a significant source of heterogeneity in development. Nevertheless, we find that mechanical responses may dampen such fluctuations, with a specific magnitude of anisotropic response that minimizes heterogeneity of tissue contours. We finally discuss how our predictions might apply to the development of plants and animals. Altogether, our results call for the systematic quantification of fluctuations in growing tissues. © 2019 National Academy of Sciences. All Rights Reserved. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163571
Appears in Collections: 气候变化与战略
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作者单位: Fruleux, A., Reproduction et Développement des Plantes, Université de Lyon, École normale supérieure de Lyon, Université Claude Bernard Lyon 1, Institut National de la Recherche Agronomique, CNRS, Lyon Cedex 07, 69364, France; Boudaoud, A., Reproduction et Développement des Plantes, Université de Lyon, École normale supérieure de Lyon, Université Claude Bernard Lyon 1, Institut National de la Recherche Agronomique, CNRS, Lyon Cedex 07, 69364, France
Recommended Citation:
Fruleux A.,Boudaoud A.. Modulation of tissue growth heterogeneity by responses to mechanical stress[J]. Proceedings of the National Academy of Sciences of the United States of America,2019-01-01,116(6)