globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1810896115
论文题名:
Self-organized shape dynamics of active surfaces
作者: Mietke A.; Jülicher F.; Sbalzarini I.F.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2019
卷: 116, 期:1
起始页码: 29
结束页码: 34
语种: 英语
英文关键词: Active fluids ; Morphogenesis ; Self-organization ; Surface mechanics
Scopus关键词: article ; geometry ; morphogenesis ; oscillation ; peristalsis ; theoretical study ; torque ; animal ; biological model ; biomechanics ; mathematics ; physiology ; surface property ; Animals ; Biomechanical Phenomena ; Mathematics ; Models, Biological ; Morphogenesis ; Surface Properties ; Torque
英文摘要: Mechanochemical processes in thin biological structures, such as the cellular cortex or epithelial sheets, play a key role during the morphogenesis of cells and tissues. In particular, they are responsible for the dynamical organization of active stresses that lead to flows and deformations of the material. Consequently, advective transport redistributes force-generating molecules and thereby contributes to a complex mechanochemical feedback loop. It has been shown in fixed geometries that this mechanism enables patterning, but the interplay of these processes with shape changes of the material remains to be explored. In this work, we study the fully self-organized shape dynamics using the theory of active fluids on deforming surfaces and develop a numerical approach to solve the corresponding force and torque balance equations. We describe the spontaneous generation of nontrivial surface shapes, shape oscillations, and directed surface flows that resemble peristaltic waves from self-organized, mechanochemical processes on the deforming surface. Our approach provides opportunities to explore the dynamics of self-organized active surfaces and can help to understand the role of shape as an integral element of the mechanochemical organization of morphogenetic processes. © 2019 National Academy of Sciences. All Rights Reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163578
Appears in Collections:气候变化与战略

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作者单位: Mietke, A., Max Planck Institute for the Physics of Complex Systems, Dresden, 01187, Germany, Chair of Scientific Computing for Systems Biology, Faculty of Computer Science, Technische Universität, Dresden, Dresden, 01187, Germany, Center for Systems Biology Dresden, Dresden, 01307, Germany, MOSAIC Group, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany; Jülicher, F., Max Planck Institute for the Physics of Complex Systems, Dresden, 01187, Germany, Center for Systems Biology Dresden, Dresden, 01307, Germany; Sbalzarini, I.F., Chair of Scientific Computing for Systems Biology, Faculty of Computer Science, Technische Universität, Dresden, Dresden, 01187, Germany, Center for Systems Biology Dresden, Dresden, 01307, Germany, MOSAIC Group, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, 01307, Germany

Recommended Citation:
Mietke A.,Jülicher F.,Sbalzarini I.F.. Self-organized shape dynamics of active surfaces[J]. Proceedings of the National Academy of Sciences of the United States of America,2019-01-01,116(1)
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