globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1722154115
论文题名:
Physics of lumen growth
作者: Dasgupta S.; Gupta K.; Zhang Y.; Viasnoff V.; Prost J.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2018
卷: 115, 期:21
起始页码: E4751
结束页码: E4757
语种: 英语
英文关键词: Lumenogenesis ; morphogenesis ; osmotic pressure
Scopus关键词: ion ; Article ; growth ; hydrostatic pressure ; intercellular space ; ion transport ; lumen ; mechanics ; molecular model ; physics ; priority journal ; steady state ; volume ; animal ; cell culture ; cell junction ; chemistry ; cytology ; liver cell ; osmosis ; physiology ; rat ; theoretical model ; Animals ; Cells, Cultured ; Hepatocytes ; Intercellular Junctions ; Models, Theoretical ; Osmosis ; Rats
英文摘要: We model the dynamics of formation of intercellular secretory lumens. Using conservation laws, we quantitatively study the balance between paracellular leaks and the build-up of osmotic pressure in the lumen. Our model predicts a critical pumping threshold to expand stable lumens. Consistently with experimental observations in bile canaliculi, the model also describes a transition between a monotonous and oscillatory regime during luminogenesis as a function of ion and water transport parameters. We finally discuss the possible importance of regulation of paracellular leaks in intercellular tubulogenesis. © 2018 National Academy of Sciences. All Rights Reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163708
Appears in Collections:气候变化与战略

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作者单位: Dasgupta, S., Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore, Laboratoire Physico Chimie Curie, Institut Curie, Paris Science et Lettres Research University, CNRS UMR168, Paris, 75005, France; Gupta, K., Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore; Zhang, Y., Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore; Viasnoff, V., Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore, CNRS Biomechanics of Cell Contacts, Singapore, 117411, Singapore, Department of Biological Sciences, National University of Singapore, Singapore, 117411, Singapore; Prost, J., Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore, Laboratoire Physico Chimie Curie, Institut Curie, Paris Science et Lettres Research University, CNRS UMR168, Paris, 75005, France

Recommended Citation:
Dasgupta S.,Gupta K.,Zhang Y.,et al. Physics of lumen growth[J]. Proceedings of the National Academy of Sciences of the United States of America,2018-01-01,115(21)
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