globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1708625114
论文题名:
Filament rigidity and connectivity tune the deformation modes of active biopolymer networks
作者: Stam S.; Freedman S.L.; Banerjee S.; Weirich K.L.; Dinner A.R.; Gardel M.L.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2017
卷: 114, 期:47
起始页码: E10037
结束页码: E10045
语种: 英语
英文关键词: Actin ; Active matter ; Agent-based simulation ; Mechanics ; Myosin
Scopus关键词: actin ; biopolymer ; molecular motor ; actin ; actin binding protein ; carrier protein ; fascin ; filamin ; myosin ; actin filament ; Article ; biopolymer structure ; compression ; connectome ; controlled study ; cross linking ; cytoskeleton ; force ; molecular mechanics ; muscle contractility ; physical parameters ; polymerization ; priority journal ; protein assembly ; rigidity ; simulation ; stress ; actin filament ; animal ; biological model ; biomechanics ; chemistry ; chicken ; computer simulation ; Leporidae ; metabolism ; microtubule ; ultrastructure ; Actin Cytoskeleton ; Actins ; Animals ; Biomechanical Phenomena ; Carrier Proteins ; Chickens ; Computer Simulation ; Cytoskeleton ; Filamins ; Microfilament Proteins ; Microtubules ; Models, Biological ; Myosins ; Rabbits
英文摘要: Molecular motors embedded within collections of actin and microtubule filaments underlie the dynamics of cytoskeletal assemblies. Understanding the physics of such motor-filament materials is critical to developing a physical model of the cytoskeleton and designing biomimetic active materials. Here, we demonstrate through experiments and simulations that the rigidity and connectivity of filaments in active biopolymer networks regulates the anisotropy and the length scale of the underlying deformations, yielding materials with variable contractility. We find that semiflexible filaments can be compressed and bent by motor stresses, yielding materials that undergo predominantly biaxial deformations. By contrast, rigid filament bundles slide without bending under motor stress, yielding materials that undergo predominantly uniaxial deformations. Networks dominated by biaxial deformations are robustly contractile over a wide range of connectivities, while networks dominated by uniaxial deformations can be tuned from extensile to contractile through cross-linking. These results identify physical parameters that control the forces generated within motor-filament arrays and provide insight into the self-organization and mechanics of cytoskeletal assemblies. © 2017, National Academy of Sciences. All rights reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163772
Appears in Collections:气候变化与战略

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作者单位: Stam, S., Biophysical Sciences Graduate Program, University of Chicago, Chicago, IL 60637, United States, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, United States; Freedman, S.L., James Franck Institute, University of Chicago, Chicago, IL 60637, United States, Department of Physics, University of Chicago, Chicago, IL 60637, United States; Banerjee, S., James Franck Institute, University of Chicago, Chicago, IL 60637, United States, Department of Physics and Astronomy, University College London, London, WC1E 6BT, United Kingdom, Institute for Physics of Living Systems, University College London, London, WC1E 6BT, United Kingdom; Weirich, K.L., James Franck Institute, University of Chicago, Chicago, IL 60637, United States; Dinner, A.R., Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, United States, James Franck Institute, University of Chicago, Chicago, IL 60637, United States, Department of Chemistry, University of Chicago, Chicago, IL 60637, United States; Gardel, M.L., Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, United States, James Franck Institute, University of Chicago, Chicago, IL 60637, United States, Department of Physics, University of Chicago, Chicago, IL 60637, United States

Recommended Citation:
Stam S.,Freedman S.L.,Banerjee S.,et al. Filament rigidity and connectivity tune the deformation modes of active biopolymer networks[J]. Proceedings of the National Academy of Sciences of the United States of America,2017-01-01,114(47)
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