globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1620179114
论文题名:
Foldamer hypothesis for the growth and sequence differentiation of prebiotic polymers
作者: Guseva E.; Zuckermann R.N.; Dill K.A.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2017
卷: 114, 期:36
起始页码: E7460
结束页码: E7468
语种: 英语
英文关键词: Autocatalytic sets ; Biopolymers ; HP model ; Origin of life
Scopus关键词: monomer ; polymer ; prebiotic agent ; protein ; polymer ; prebiotic agent ; Article ; catalysis ; catalyst ; chemical binding ; hydrophobicity ; molecular dynamics ; molecular model ; polymerization ; priority journal ; ribosome ; biogenesis ; chemical phenomena ; chemistry ; polymerization ; protein folding ; Catalysis ; Hydrophobic and Hydrophilic Interactions ; Origin of Life ; Polymerization ; Polymers ; Prebiotics ; Protein Folding ; Proteins
英文摘要: It is not known how life originated. It is thought that prebiotic processes were able to synthesize short random polymers. However, then, how do short-chain molecules spontaneously grow longer? Also, how would random chains grow more informational and become autocatalytic (i.e., increasing their own concentrations)? We study the folding and binding of random sequences of hydrophobic (H) and polar (P) monomers in a computational model. We find that even short hydrophobic polar (HP) chains can collapse into relatively compact structures, exposing hydrophobic surfaces. In this way, they act as primitive versions of today’s protein catalysts, elongating other such HP polymers as ribosomes would now do. Such foldamer catalysts are shown to form an autocatalytic set, through which short chains grow into longer chains that have particular sequences. An attractive feature of this model is that it does not overconverge to a single solution; it gives ensembles that could further evolve under selection. This mechanism describes how specific sequences and conformations could contribute to the chemistry-to-biology (CTB) transition. © 2017, National Academy of Sciences. All rights reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163801
Appears in Collections:气候变化与战略

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作者单位: Guseva, E., Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794, United States, Department of Chemistry, Stony Brook University, Stony Brook, NY 11794, United States, Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY 11794, United States; Zuckermann, R.N., Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States; Dill, K.A., Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794, United States, Department of Chemistry, Stony Brook University, Stony Brook, NY 11794, United States, Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY 11794, United States

Recommended Citation:
Guseva E.,Zuckermann R.N.,Dill K.A.. Foldamer hypothesis for the growth and sequence differentiation of prebiotic polymers[J]. Proceedings of the National Academy of Sciences of the United States of America,2017-01-01,114(36)
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