DOI: 10.1073/pnas.1914330117
论文题名: Testing the utility of dental morphological trait combinations for inferring human neutral genetic variation
作者: Rathmann H. ; Reyes-Centeno H.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2020
卷: 117, 期: 20 起始页码: 10769
结束页码: 10777
语种: 英语
英文关键词: ASUDAS
; Bioarchaeology
; Biodistance
; Dental morphology
; Genetic drift
Scopus关键词: article
; controlled study
; genetic drift
; genetic variation
; human
; morphological trait
; natural selection
; population dynamics
; anatomy and histology
; population genetics
; procedures
; quantitative trait
; tooth
; Genetic Variation
; Genetics, Population
; Humans
; Quantitative Trait, Heritable
; Tooth
英文摘要: Researchers commonly rely on human dental morphological features in order to reconstruct genetic affinities among past individuals and populations, particularly since teeth are often the best preserved part of a human skeleton. Tooth form is considered to be highly heritable and selectively neutral and, therefore, to be an excellent proxy for DNA when none is available. However, until today, it remains poorly understood whether certain dental traits or trait combinations preserve neutral genomic signatures to a greater degree than others. Here, we address this long-standing research gap by systematically testing the utility of 27 common dental traits and >134 million possible trait combinations in reflecting neutral genomic variation in a worldwide sample of modern human populations. Our analyses reveal that not all traits are equally well-suited for reconstructing population affinities. Whereas some traits largely reflect neutral variation and therefore evolved primarily as a result of genetic drift, others can be linked to nonstochastic processes such as natural selection or hominin admixture. We also demonstrate that reconstructions of population affinity based on many traits are not necessarily more reliable than those based on only a few traits. Importantly, we find a set of highly diagnostic trait combinations that preserve neutral genetic signals best (up to x~r = 0.580; 95% r range = 0.293 to 0.758; P = 0.001). We propose that these trait combinations should be prioritized in future research, as they allow for more accurate inferences about past human population dynamics when using dental morphology as a proxy for DNA. © 2020 National Academy of Sciences. All rights reserved. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/164210
Appears in Collections: 气候变化与战略
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作者单位: Rathmann, H., Deutsche Forschungsgemeinschaft Center for Advanced Studies “Words, Bones, Genes, Tools, University of Tübingen, Tübingen, 72070, Germany; Reyes-Centeno, H., Deutsche Forschungsgemeinschaft Center for Advanced Studies “Words, Bones, Genes, Tools, University of Tübingen, Tübingen, 72070, Germany
Recommended Citation:
Rathmann H.,Reyes-Centeno H.. Testing the utility of dental morphological trait combinations for inferring human neutral genetic variation[J]. Proceedings of the National Academy of Sciences of the United States of America,2020-01-01,117(20)