DOI: 10.1073/pnas.1919485117
论文题名: The impact of long-range dispersal on gene surfing
作者: Paulose J. ; Hallatschek O.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2020
卷: 117, 期: 14 起始页码: 7584
结束页码: 7593
语种: 英语
英文关键词: Long-range dispersal
; Neutral genetic diversity
; Range expansions
Scopus关键词: Article
; coarse grained model
; controlled study
; gene frequency
; genetic analysis
; genetic distance
; genetic model
; genetic variation
; heterozygosity
; long range dispersal
; mutational analysis
; population dispersal
; priority journal
; qualitative analysis
; simulation
; species invasion
; allele
; animal
; biological model
; genetic variation
; heterozygote
; molecular dynamics
; physiology
; population migration
; time factor
; Alleles
; Animal Migration
; Animals
; Genetic Variation
; Heterozygote
; Models, Genetic
; Molecular Dynamics Simulation
; Time Factors
英文摘要: Range expansions lead to distinctive patterns of genetic variation in populations, even in the absence of selection. These patterns and their genetic consequences have been well studied for populations advancing through successive short-ranged migration events. However, most populations harbor some degree of long-range dispersal, experiencing rare yet consequential migration events over arbitrarily long distances. Although dispersal is known to strongly affect spatial genetic structure during range expansions, the resulting patterns and their impact on neutral diversity remain poorly understood. Here, we systematically study the consequences of long-range dispersal on patterns of neutral variation during range expansion in a class of dispersal models which spans the extremes of local (effectively short-ranged) and global (effectively well-mixed) migration. We find that sufficiently long-ranged dispersal leaves behind a mosaic of monoallelic patches, whose number and size are highly sensitive to the distribution of dispersal distances. We develop a coarse-grained model which connects statistical features of these spatial patterns to the evolution of neutral diversity during the range expansion. We show that growth mechanisms that appear qualitatively similar can engender vastly different outcomes for diversity: Depending on the tail of the dispersal distance distribution, diversity can be either preserved (i.e., many variants survive) or lost (i.e., one variant dominates) at long times. Our results highlight the impact of spatial and migratory structure on genetic variation during processes as varied as range expansions, species invasions, epidemics, and the spread of beneficial mutations in established populations. © 2020 National Academy of Sciences. All rights reserved. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/164261
Appears in Collections: 气候变化与战略
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作者单位: Paulose, J., Institute for Fundamental Science, University of Oregon, Eugene, OR 97403, United States, Department of Physics, University of Oregon, Eugene, OR 97403, United States; Hallatschek, O., Department of Physics, University of California, Berkeley, CA 94720, United States, Department of Integrative Biology, University of California, Berkeley, CA 94720, United States
Recommended Citation:
Paulose J.,Hallatschek O.. The impact of long-range dispersal on gene surfing[J]. Proceedings of the National Academy of Sciences of the United States of America,2020-01-01,117(14)