globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1918232117
论文题名:
Footprints of natural selection at the mannose-6phosphate isomerase locus in barnacles
作者: Nunez J.C.B.; Flight P.A.; Neil K.B.; Rong S.; Eriksson L.A.; Ferranti D.A.; Rosenblad M.A.; Blomberg A.; Rand D.M.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2020
卷: 117, 期:10
起始页码: 5376
结束页码: 5385
语种: 英语
英文关键词: Balancing selection ; Barnacles ; Ecological genomics ; Population genetics ; Semibalanus balanoides
Scopus关键词: alloenzyme ; amino acid ; mannose phosphate isomerase ; isoenzyme ; mannose phosphate isomerase ; 5' untranslated region ; allele ; amino acid polymorphism ; Article ; controlled study ; DNA footprinting ; exon ; gene frequency ; gene function ; gene locus ; gene mutation ; gene sequence ; gene structure ; genetic code ; genetic heterogeneity ; genetic variability ; genotype ; haplotype ; Mpi gene ; nonhuman ; priority journal ; protein structure ; Semibalanus balanoides ; Semibalanus cariosus ; single nucleotide polymorphism ; taxon ; animal ; barnacle ; chemistry ; enzymology ; gene locus ; genetic polymorphism ; genetic selection ; genetics ; mutation ; Alleles ; Animals ; Genetic Loci ; Genotype ; Isoenzymes ; Mannose-6-Phosphate Isomerase ; Mutation ; Polymorphism, Genetic ; Selection, Genetic ; Thoracica
英文摘要: The mannose-6-phosphate isomerase (Mpi) locus in Semibalanus balanoides has been studied as a candidate gene for balancing selection for more than two decades. Previous work has shown that Mpi allozyme genotypes (fast and slow) have different frequencies across Atlantic intertidal zones due to selection on post-settlement survival (i.e., allele zonation). We present the complete gene sequence of the Mpi locus and quantify nucleotide polymorphism in S. balanoides, as well as divergence to its sister taxon Semibalanus cariosus. We show that the slow allozyme contains a derived charge-altering amino acid polymorphism, and both allozyme classes correspond to two haplogroups with multiple internal haplotypes. The locus shows several footprints of balancing selection around the fast/slow site: an enrichment of positive Tajima’s D for nonsynonymous mutations, an excess of polymorphism, and a spike in the levels of silent polymorphism relative to silent divergence, as well as a site frequency spectrum enriched for midfrequency mutations. We observe other departures from neutrality across the locus in both coding and noncoding regions. These include a nonsynonymous trans-species polymorphism and a recent mutation under selection within the fast haplogroup. The latter suggests ongoing allelic replacement of functionally relevant amino acid variants. Moreover, predicted models of Mpi protein structure provide insight into the functional significance of the putatively selected amino acid polymorphisms. While footprints of selection are widespread across the range of S. balanoides, our data show that intertidal zonation patterns are variable across both spatial and temporal scales. These data provide further evidence for heterogeneous selection on Mpi. © 2020 National Academy of Sciences. All rights reserved.
Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/164293
Appears in Collections:气候变化与战略

Files in This Item:

There are no files associated with this item.


作者单位: Nunez, J.C.B., Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, United States; Flight, P.A., Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, United States; Neil, K.B., Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, United States; Rong, S., Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, United States, Center for Computational Molecular Biology, Brown University, Providence, RI 02912, United States; Eriksson, L.A., Department of Chemistry and Molecular Biology, Lundberg Laboratory, University of Gothenburg, Göteborg, 405 30, Sweden; Ferranti, D.A., Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, United States; Rosenblad, M.A., Department of Chemistry and Molecular Biology, Lundberg Laboratory, University of Gothenburg, Göteborg, 405 30, Sweden; Blomberg, A., Department of Chemistry and Molecular Biology, Lundberg Laboratory, University of Gothenburg, Göteborg, 405 30, Sweden; Rand, D.M., Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, United States

Recommended Citation:
Nunez J.C.B.,Flight P.A.,Neil K.B.,et al. Footprints of natural selection at the mannose-6phosphate isomerase locus in barnacles[J]. Proceedings of the National Academy of Sciences of the United States of America,2020-01-01,117(10)
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Nunez J.C.B.]'s Articles
[Flight P.A.]'s Articles
[Neil K.B.]'s Articles
百度学术
Similar articles in Baidu Scholar
[Nunez J.C.B.]'s Articles
[Flight P.A.]'s Articles
[Neil K.B.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Nunez J.C.B.]‘s Articles
[Flight P.A.]‘s Articles
[Neil K.B.]‘s Articles
Related Copyright Policies
Null
收藏/分享
所有评论 (0)
暂无评论
 

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.