DOI: 10.1111/ele.13426
论文题名: The association between stressors and telomeres in non-human vertebrates: a meta-analysis
作者: Chatelain M. ; Drobniak S.M. ; Szulkin M.
刊名: Ecology Letters
ISSN: 1461023X
出版年: 2020
卷: 23, 期: 2 起始页码: 381
结束页码: 398
语种: 英语
中文关键词: Ageing
; competition
; habitat quality
; oxidative stress
; reproduction
; senescence
; stressor
; telomere
英文关键词: age
; behavioral response
; bioenergetics
; cell
; competition (ecology)
; environmental conditions
; environmental stress
; habitat quality
; mitochondrion
; oxidative stress
; reactive oxygen species
; reproduction
; senescence
; Animalia
; Vertebrata
; animal
; cell aging
; meta analysis
; phylogeny
; telomere
; telomere shortening
; vertebrate
; Animals
; Cellular Senescence
; Phylogeny
; Telomere
; Telomere Shortening
; Vertebrates
英文摘要: Animal response to stressors such as harsh environmental conditions and demanding biological processes requires energy generated through increased mitochondrial activity. This results in the production of reactive oxygen species (ROS). In vitro and some in vivo studies suggest that oxidative damage of DNA caused by ROS is responsible for telomere shortening. Since telomere length is correlated with survival in many vertebrates, telomere loss is hypothesised to trigger cellular ageing and/ or to reflect the harshness of the environment an individual has experienced. To improve our understanding of stress-induced telomere dynamics in non-human vertebrates, we analysed 109 relevant studies in a meta-analytical framework. Overall, the exposure to possible stressors was associated with shorter telomeres or higher telomere shortening rate (average effect size = −0.16 ± 0.03). This relationship was consistent for all phylogenetic classes and for all a priori-selected stressor categories. It was stronger in the case of pathogen infection, competition, reproductive effort and high activity level, which emphasises their importance in explaining intraspecific telomere length variability and, potentially, lifespan variability. Interestingly, the association between stressor exposure and telomeres in one hand, and oxidative stress in the other hand, covaried, suggesting the implication of oxidative stress in telomere dynamics. © 2019 John Wiley & Sons Ltd/CNRS Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/166605
Appears in Collections: 气候变化与战略
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作者单位: Centre of New Technologies, University of Warsaw, Banacha 2C, Warszawa, 02-097, Poland; Institute of Environmental Sciences, Jagiellonian University, Gronostajowa 7, Kraków, 30-387, Poland; Ecology & Evolution Research Centre, School of Biological, Environmental and Earth Sciences, University of New South Wales, Sydney, Australia
Recommended Citation:
Chatelain M.,Drobniak S.M.,Szulkin M.. The association between stressors and telomeres in non-human vertebrates: a meta-analysis[J]. Ecology Letters,2020-01-01,23(2)