globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2020.01.017
论文题名:
Enantioselective synthesis of mixed 3,3′-bisindoles via a phosphine-catalyzed umpolung γ-addition of 3′-indolyl-3-oxindoles to allenoates
作者: Tasdan Y.; Mei G.-J.; Lu Y.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2020
卷: 65, 期:7
起始页码: 557
结束页码: 563
语种: 英语
中文关键词: Allenoates ; Amino acid-derived bifunctional phosphine ; Formal total syntheses ; Mixed 3,3′-Bisindole ; Umpolung γ-addition
英文关键词: Addition reactions ; Amino acids ; Catalysis ; Organic compounds ; Phosphorus compounds ; Scaffolds ; Synthesis (chemical) ; Allenoates ; Bi-functional ; Enantioselective ; Enantioselective synthesis ; Stereogenic centers ; Synthetic intermediates ; Total synthesis ; Umpolung ; Enantioselectivity
英文摘要: An enantioselective umpolung γ-addition reaction of 3′-indolyl-3-oxindoles to allenoates catalyzed by amino acid-derived bifunctional phosphine catalysts has been developed. A wide range of chiral mixed 3,3′-bisindole scaffolds containing an all-carbon quaternary stereogenic center were obtained in high yields and with excellent enantioselectivities. 3,3′-Bisindoles are valuable synthetic intermediates, the employment of which led to formal total syntheses of (+)-Chimonanthine, (+)-Folicanthine and (−)-Calycanthine, as well as facile creation of useful pyrrolidinoindoline core structure. © 2020 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170050
Appears in Collections:气候变化与战略

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作者单位: Department of Chemistry, National University of Singapore, Singapore 117543, Singapore; Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Fuzhou, 359297, China; National University of Singapore (Suzhou) Research Institute, Suzhou Industrial Park, Suzhou, 215123, China

Recommended Citation:
Tasdan Y.,Mei G.-J.,Lu Y.. Enantioselective synthesis of mixed 3,3′-bisindoles via a phosphine-catalyzed umpolung γ-addition of 3′-indolyl-3-oxindoles to allenoates[J]. Science Bulletin,2020-01-01,65(7)
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