globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2019.12.024
论文题名:
Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy
作者: Zhang Y.; Wan Y.; Liao Y.; Hu Y.; Jiang T.; He T.; Bi W.; Lin J.; Gong P.; Tang L.; Huang P.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2020
卷: 65, 期:7
起始页码: 564
结束页码: 572
语种: 英语
中文关键词: Fenton-like reaction ; Glucose oxidase ; Janus nanoparticles ; Synergistic therapy ; Theranostics
英文关键词: Catalysis ; Diseases ; Glucose ; Glucose oxidase ; Glucose sensors ; Magnetic resonance ; Nanoparticles ; Oxidation ; Tumors ; Catalytic efficiencies ; Fenton-like reactions ; Glucose oxidases (GOx) ; Janus nanoparticles ; Synergistic therapy ; Theranostics ; Therapeutic efficacy ; Tumor microenvironment ; Hematite
英文摘要: Multimodal cancer synergistic therapy exhibited remarkable advantages over monotherapy in producing an improved therapeutic efficacy. In this work, Janus-type γ-Fe2O3/SiO2 nanoparticles (JFSNs) are conjugated with glucose oxidase (GOx) for synergistic cancer starvation/chemodynamic therapy. The γ-Fe2O3 hemisphere of JFSNs can perform photoacoustic/T2 magnetic resonance dual-modal imaging of tumors. GOx on the surface of JFSNs catalyzes the decomposition of glucose and produces H2O2 for cancer starvation therapy. Subsequently, the γ-Fe2O3 hemisphere catalyzes the disproportionation of H2O2 to generate highly reactive hydroxyl radicals in an acidic tumor microenvironment. The close distance between GOx and JFSNs ensures adequate contact between the γ-Fe2O3 hemisphere and its substrate H2O2, thus enhancing the catalytic efficiency. This synergy of glucose depletion, biotoxic H2O2 and hydroxyl radicals significantly suppresses 4T1 mammary tumor growth with minimal adverse effects. © 2020 Science China Press
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被引频次[WOS]:88   [查看WOS记录]     [查看WOS中相关记录]
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170166
Appears in Collections:气候变化与战略

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作者单位: Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, 518060, China; State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310027, China; Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China; Department of General Surgery, Shenzhen University General Hospital, Shenzhen, 518055, China

Recommended Citation:
Zhang Y.,Wan Y.,Liao Y.,et al. Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy[J]. Science Bulletin,2020-01-01,65(7)
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