globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2021.05.018
论文题名:
Characterization of exploratory patterns and hippocampal–prefrontal network oscillations during the emergence of free exploration
作者: Dong W.; Chen H.; Sit T.; Han Y.; Song F.; Vyssotski A.L.; Gross C.T.; Si B.; Zhan Y.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
语种: 英语
中文关键词: Entropy ; Exploration ; Hippocampus ; Neural oscillations ; Prefrontal cortex
英文摘要: During free exploration, the emergence of patterned and sequential behavioral responses to an unknown environment reflects exploration traits and adaptation. However, the behavioral dynamics and neural substrates underlying the exploratory behavior remain poorly understood. We developed computational tools to quantify the exploratory behavior and performed in vivo electrophysiological recordings in a large arena in which mice made sequential excursions into unknown territory. Occupancy entropy was calculated to characterize the cumulative and moment-to-moment behavioral dynamics in explored and unexplored territories. Local field potential analysis revealed that the theta activity in the dorsal hippocampus (dHPC) was highly correlated with the occupancy entropy. Individual dHPC and prefrontal cortex (PFC) oscillatory activities could classify various aspects of free exploration. Initiation of exploration was accompanied by a coordinated decrease and increase in theta activity in PFC and dHPC, respectively. Our results indicate that dHPC and PFC work synergistically in shaping free exploration by modulating exploratory traits during emergence and visits to an unknown environment. © 2021 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170236
Appears in Collections:气候变化与战略

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作者单位: Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Key Laboratory of Translational Research for Brain Diseases, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China; State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China; Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang, 110169, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Institute of Neuroinformatics, the University of Zürich and Swiss Federal Institute of Technology (ETH), Zurich, CH-8057, Switzerland; European Molecular Biology Laboratory (EMBL), Monterotondo, 00015, Italy; School of Systems Science, Beijing Normal University, Beijing, 100875, China

Recommended Citation:
Dong W.,Chen H.,Sit T.,et al. Characterization of exploratory patterns and hippocampal–prefrontal network oscillations during the emergence of free exploration[J]. Science Bulletin,2021-01-01
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