globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2021.01.003
论文题名:
Pairwise interactions in gene expression determine a hierarchical transcriptional profile in the human brain
作者: Hua J.; Yang Z.; Jiang T.; Yu S.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期:14
起始页码: 1437
结束页码: 1447
语种: 英语
中文关键词: Co-expression ; Functional network ; Gene-gene interaction ; Higher-order interactions ; Structural network
英文关键词: Complex networks ; Transcription ; Co-expression ; Functional network ; Gene-gene interaction ; Genes expression ; High-order ; High-order interaction ; Higher-order ; Human brain ; Pairwise interaction ; Structural networks ; Brain
英文摘要: The orchestrated expression of thousands of genes gives rise to the complexity of the human brain. However, the structures governing these myriad gene-gene interactions remain unclear. By analyzing transcription data from more than 2000 sites in six human brains, we found that pairwise interactions between genes, without considering any higher-order interactions, are sufficient to predict the transcriptional pattern of the genome for individual brain regions and the transcriptional profile of the entire brain consisting of more than 200 areas. These findings suggest a quadratic complexity of transcriptional patterns in the human brain, which is much simpler than expected. In addition, using a pairwise interaction model, we revealed that the strength of gene-gene interactions in the human brain gives rise to the nearly maximal number of transcriptional clusters, which may account for the functional and structural richness of the brain. © 2021 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170272
Appears in Collections:气候变化与战略

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作者单位: Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, 100049, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, 100190, China; School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049, China

Recommended Citation:
Hua J.,Yang Z.,Jiang T.,et al. Pairwise interactions in gene expression determine a hierarchical transcriptional profile in the human brain[J]. Science Bulletin,2021-01-01,66(14)
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