DOI: 10.1016/j.scib.2021.02.018
论文题名: Low levels of low-density lipoprotein cholesterol and cognitive decline
作者: Hua R. ; Ma Y. ; Li C. ; Zhong B. ; Xie W.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期: 16 起始页码: 1684
结束页码: 1690
语种: 英语
中文关键词: Cognitive decline
; Longitudinal cohort study
; Low-density lipoprotein cholesterol
; The Health and Retirement Study
英文关键词: Brain
; Cholesterol
; Lipoproteins
; Cardiovascular event
; Cognitive decline
; Cognitive functions
; Confidence interval
; High-risk individuals
; Low density lipoproteins
; Randomized controlled trial
; Recommended values
; Population statistics
英文摘要: The relationship between low levels of serum low-density lipoprotein cholesterol (LDL-C) and subsequent cognitive decline remains unclear. The present study aimed to evaluate the longitudinal association between low LDL-C levels and cognition decline in the context of the current aggressive guideline-recommended targets (LDL-C levels less than 55 mg/dL for individuals at very high risk of cardiovascular events, and less than 70 mg/dL for high risk individuals). Data from wave 13 (2016) to wave 14 (2018) of the Health and Retirement Study (HRS) were utilized. LDL-C concentrations measured at wave 13 were categorized into 5 levels, reflecting currently recommended values for lipid lowering treatment. Of 7129 included participants (mean age: 69.0 ± 9.9 years, 60.3% female), we found that compared to participants with LDL-C levels of 70.0–99.9 mg/dL, those with LDL-C levels of <55 mg/dL had significantly slower 2-year decline rates in global cognitive function (0.244 point/year; 95% confidence interval (CI): 0.065−0.422; P = 0.008), working memory (0.068 point/year; 95% CI: 0.004−0.133; P = 0.038), and borderline significantly in episodic memory (0.155 point/year; 95% CI: −0.004−0.315; P = 0.057). Similarly, significantly slower decline rates were observed in those with LDL-C levels of 55.0–69.9 mg/dL. The present study demonstrated that compared with LDL-C levels 70.0–99.9 mg/dL, low LDL-C levels (<70 mg/dL, especially <55 mg/dL) were associated with significantly slower cognitive decline in population-based setting. Future randomized controlled trials are warranted to ascertain the safety and benefit of current aggressive guideline-recommended targets on cognitive function. © 2021 Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170273
Appears in Collections: 气候变化与战略
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作者单位: Heart and Vascular Health Research Center, Peking University Clinical Research Institute, Peking University First Hospital, Beijing, 100191, China; Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing, 100191, China; Department of Geriatric Psychiatry, Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, 430030, China
Recommended Citation:
Hua R.,Ma Y.,Li C.,et al. Low levels of low-density lipoprotein cholesterol and cognitive decline[J]. Science Bulletin,2021-01-01,66(16)