DOI: 10.1016/j.scib.2021.01.032
论文题名: Schizophrenia: a classic battle ground of nature versus nurture debate
作者: St Clair D. ; Lang B.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期: 10 起始页码: 1037
结束页码: 1046
语种: 英语
中文关键词: Nature
; Nurture
; Omnigenic
; Schizophrenia
英文关键词: Environmental risk factor
; Genetic architecture
; Genetic risks
; Mental illness
; Multilevels
; Novel methods
; Diseases
英文摘要: Much has been learned about the etiology and pathogenesis of schizophrenia since the term was first used by Eugene Bleuler over a century ago to describe one of the most important forms of major mental illness to affect mankind. Both nature and nurture feature prominently in our understanding of the genesis of the overall risk of developing schizophrenia. We now have a firm grasp of the broad structure of the genetic architecture and several key environmental risk factors have been identified and delineated. However, much of the heritability of schizophrenia remains unexplained and the reported environmental risk factors do not explain all the variances not attributable to genetic risk factors. The biggest problem at present is that our understanding of the causal mechanisms involved is still in its infancy. In this review, we describe the extent and limits of our knowledge of the specific genetic/constitutional and non-genetic/environmental factors that contribute to the overall risk of schizophrenia. We suggest novel methods may be required to understand the almost certainly immensely complex multi-level causal mechanisms that contribute to the generation of the schizophrenia phenotype. © 2021 Science China Press Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170390
Appears in Collections: 气候变化与战略
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作者单位: Department of Psychiatry, The Second Xiangya Hospital, Central South University, National Clinical Research Center for Mental Disorders, Changsha, 410011, China; Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom; Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, 200030, China
Recommended Citation:
St Clair D.,Lang B.. Schizophrenia: a classic battle ground of nature versus nurture debate[J]. Science Bulletin,2021-01-01,66(10)