globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2020.10.020
论文题名:
On-demand degradable magnetic resonance imaging nanoprobes
作者: Sun W.; Wang Z.; Liu J.; Jiang C.; Chen W.; Yu B.; Wang W.; Lu L.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期:7
起始页码: 676
结束页码: 684
语种: 英语
中文关键词: DNA-based ; MRI reporter ; On-demand degradation ; Photothermal melting ; Theranostic nanoprobes
英文关键词: Chemotherapy ; Diagnosis ; Gadolinium ; Mammals ; Nanoprobes ; Theranostics ; Antitumor effect ; Cancer diagnostics ; Clinical application ; MRI reporter genes ; Photothermal melting ; Photothermal therapy ; Polydopamine ; Single platform ; Magnetic resonance imaging
英文摘要: Theranostic nanoprobes can potentially integrate imaging and therapeutic capabilities into a single platform, offering a new personalized cancer diagnostic tool. However, there is a growing concern that their clinical application is not safe, particularly due to metal-containing elements, such as the gadolinium used in magnetic resonance imaging (MRI). We demonstrate for the first time that the photothermal melting of the DNA duplex helix was a reliable and versatile strategy that enables the on-demand degradation of the gadolinium-containing MRI reporter gene from polydopamine (PDA)-based theranostic nanoprobes. The combination of chemotherapy (doxorubicin) and photothermal therapy, which leads to the enhanced anti-tumor effect. In vivo MRI tracking reveals that renal filtration was able to rapidly clear the free gadolinium-containing MRI reporter from the mice body. This results in a decrease in the long-term toxic effect of theranostic MRI nanoprobes. Our findings may pave the way to address toxicity issues of the theranostic nanoprobes. © 2020 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170396
Appears in Collections:气候变化与战略

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作者单位: College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Instrumental Analysis Center of Qingdao University, Qingdao University, Qingdao, 266071, China; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; Department of Radiology, Second Hospital of Jilin University, Changchun, 130041, China

Recommended Citation:
Sun W.,Wang Z.,Liu J.,et al. On-demand degradable magnetic resonance imaging nanoprobes[J]. Science Bulletin,2021-01-01,66(7)
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