globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2021.01.002
论文题名:
Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa
作者: Wang Y.; Cao Q.; Cao Q.; Gan J.; Sun N.; Yang C.-G.; Bae T.; Wu M.; Lan L.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期:11
起始页码: 1101
结束页码: 1118
语种: 英语
中文关键词: Histamine ; Host-microbe interaction ; Metabolism ; Pseudomonas aeruginosa ; Virulence
英文关键词: Biochemistry ; Metabolites ; Transcription ; Bacterial cells ; Cellular process ; Human pathogens ; Iron acquisition ; Pathogenic bacterium ; Pseudomonas aeruginosa ; Regulatory signals ; Transcriptional regulator ; Bacteria
英文摘要: During infections, bacteria stimulate host cells to produce and release histamine, which is a key mediator of vital cellular processes in animals. However, the mechanisms underlying the bacterial cell's ability to sense and respond to histamine are poorly understood. Herein, we show that HinK, a LysR-type transcriptional regulator, is required to evoke responses to histamine in Pseudomonas aeruginosa, an important human pathogen. HinK directly binds to and activates the promoter of genes involved in histamine uptake and metabolism, iron acquisition, and Pseudomonas quinolone signal (PQS) biosynthesis. The transcriptional regulatory activity of HinK is induced when histamine is present, and it occurs when HinK binds with imidazole-4-acetic acid (ImAA), a histamine metabolite whose production in P. aeruginosa depends on the HinK-activated histamine uptake and utilization operon hinDAC-pa0222. Importantly, the inactivation of HinK inhibits diverse pathogenic phenotypes of P. aeruginosa. These results suggest that histamine acts as an interkingdom signal and provide insights into the mechanism used by pathogenic bacteria to exploit host regulatory signals to promote virulence. © 2021 Science China Press
Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170435
Appears in Collections:气候变化与战略

Files in This Item:

There are no files associated with this item.


作者单位: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; College of Life Science, Northwest University, Xi'an, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China; State Key Laboratory of Genetic Engineering, Shanghai Public Health Clinical Center, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 201438, China; The State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China; Department of Microbiology and Immunology, Indiana University School of Medicine-Northwest, Gary, IN 46408, United States; Department of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58203-9037, United States; NMPA Key Laboratory for Testing Technology of Pharmaceutical Microbiology, Shanghai Institute for Food and Drug Control, Shanghai, 201203, China

Recommended Citation:
Wang Y.,Cao Q.,Cao Q.,et al. Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa[J]. Science Bulletin,2021-01-01,66(11)
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang Y.]'s Articles
[Cao Q.]'s Articles
[Cao Q.]'s Articles
百度学术
Similar articles in Baidu Scholar
[Wang Y.]'s Articles
[Cao Q.]'s Articles
[Cao Q.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang Y.]‘s Articles
[Cao Q.]‘s Articles
[Cao Q.]‘s Articles
Related Copyright Policies
Null
收藏/分享
所有评论 (0)
暂无评论
 

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.