globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2021.06.002
论文题名:
Optimizing antithymocyte globulin dosing in haploidentical hematopoietic cell transplantation: long-term follow-up of a multicenter, randomized controlled trial
作者: Wang Y.; Liu Q.-F.; Lin R.; Yang T.; Xu Y.-J.; Mo X.-D.; Huang X.-J.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
语种: 英语
中文关键词: Antithymocyte globulin ; Chronic graft-versus-host disease ; GVHD-free/relapse-free survival ; Haematopoietic cell transplantation ; Haploidentical ; Late effects
英文关键词: Cytology ; Graft vs. host reactions ; Grafting (chemical) ; Grafts ; Viruses ; Antithymocyte globulin ; Cell transplantation ; Confidence interval ; Graft-versus-host disease ; Graft-versus-host disease-free/relapse-free survival ; Haploidentical ; Hazard ratio ; Hematopoietic cell ; Hematopoietic cell transplantation ; Late effects ; Cells
英文摘要: Given that randomized studies testing the long-term impact of antithymocyte globulin (ATG) dosing are scarce, we report the results of an extended follow-up from the original trial. In our prospective, multicenter, randomized trial, 408 leukemia patients 14–65 years of age who underwent haploidentical hematopoietic cell transplantation (haplo-HCT) under our original “Beijing protocol” were randomly assigned one-to-one to ATG doses of 7.5 mg/kg (n = 203, ATG-7.5) or 10 mg/kg (n = 205, ATG-10.0) at four sites. Extended follow-up (median 1968 d (range: 1300–2710 d) indicated comparable 5-year probabilities of moderate-to-severe chronic graft-versus-host disease (GVHD) (hazard ratio (HR): 1.384, 95% confidence interval (CI): 0.876–2.189, P = 0.164), nonrelapse mortality (HR: 0.814, 95% CI: 0.526–1.261, P = 0.357), relapse (HR: 1.521, 95% CI: 0.919–2.518, P = 0.103), disease-free survival (HR: 1.074, 95% CI: 0.783–1.473, P = 0.658), and GVHD-free/relapse-free survival (HR: 1.186, 95% CI: 0.904–1.555, P = 0.219) between groups (ATG-7.5 vs. ATG-10.0). The 5-year rate of late effects did not differ significantly. However, the cytomegalovirus/Epstein-Barr virus-related death rate was much higher in the ATG-10.0 cohort than in the ATG-7.5 cohort (9.8% vs. 1.5%; P = 0.003). In summary, patients undergoing haplo-HCT benefit from 7.5 mg/kg ATG compared to 10.0 mg/kg ATG based on a balance between GVHD and infection control. ATG (7.5 mg/kg) is potentially regarded as the standard regimen in the platform. These results support the optimization of ATG use in the “Beijing Protocol”, especially considering the potential economic advantage in developing countries. © 2021 Science China Press
Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170436
Appears in Collections:气候变化与战略

Files in This Item:

There are no files associated with this item.


作者单位: Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China; Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; Department of Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, 350001, China; Department of Hematology, Xiangya Hospital, Central South University, Changsha, 410008, China; Collaborative Innovation Center of Hematology, Peking University, Beijing, 100044, China; Peking-Tsinghua Center for Life Sciences, Beijing, 100871, China

Recommended Citation:
Wang Y.,Liu Q.-F.,Lin R.,et al. Optimizing antithymocyte globulin dosing in haploidentical hematopoietic cell transplantation: long-term follow-up of a multicenter, randomized controlled trial[J]. Science Bulletin,2021-01-01
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang Y.]'s Articles
[Liu Q.-F.]'s Articles
[Lin R.]'s Articles
百度学术
Similar articles in Baidu Scholar
[Wang Y.]'s Articles
[Liu Q.-F.]'s Articles
[Lin R.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang Y.]‘s Articles
[Liu Q.-F.]‘s Articles
[Lin R.]‘s Articles
Related Copyright Policies
Null
收藏/分享
所有评论 (0)
暂无评论
 

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.