globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2020.10.014
论文题名:
A cilium-independent role for intraflagellar transport 88 in regulating angiogenesis
作者: Yang Y.; Chen M.; Li J.; Hong R.; Yang J.; Yu F.; Li T.; Yang S.; Ran J.; Guo C.; Zhao Y.; Luan Y.; Liu M.; Li D.; Xie S.; Zhou J.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期:7
起始页码: 727
结束页码: 739
语种: 英语
中文关键词: Angiogenesis ; Cell division ; Cell migration ; Cilium ; IFT88 ; Microtubule stability
英文关键词: Endothelial cells ; Mammals ; Proteins ; Angiogenic process ; Cellular process ; Intraflagellar transports ; Mechanistic studies ; Mechanosensors ; Microtubule stability ; Vascular development ; Vascular endothelial cells ; Blood vessels
英文摘要: Endothelial cilia are microtubule-based hair-like protrusions in the lumen of blood vessels that function as fluid mechanosensors to regulate vascular hemodynamics. However, the functions of endothelial cilia in vascular development remain controversial. In this study, depletion of several key proteins responsible for ciliogenesis allows us to identify a cilium-independent role for intraflagellar transport 88 (IFT88) in mammalian angiogenesis. Disruption of primary cilia by heat shock does not affect the angiogenic process. However, depletion of IFT88 significantly inhibits angiogenesis both in vitro and in vivo. IFT88 mediates angiogenesis by regulating the migration, polarization, proliferation, and oriented division of vascular endothelial cells. Further mechanistic studies demonstrate that IFT88 interacts with γ-tubulin and microtubule plus-end tracking proteins and promotes microtubule stability. Our findings indicate that IFT88 regulates angiogenesis through its actions in microtubule-based cellular processes, independent of its role in ciliogenesis. © 2020 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170474
Appears in Collections:气候变化与战略

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作者单位: College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of the Ministry of Education, Tianjin Key Laboratory of Protein Science, Nankai University, Tianjin, 300071, China; College of Life Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, Institute of Biomedical Sciences, Shandong Normal University, Jinan, 250014, China; Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China

Recommended Citation:
Yang Y.,Chen M.,Li J.,et al. A cilium-independent role for intraflagellar transport 88 in regulating angiogenesis[J]. Science Bulletin,2021-01-01,66(7)
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