globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2021.01.025
论文题名:
IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota-dependent manner
作者: Zheng X.; Liu L.; Meng G.; Zhu S.; Zhou R.; Jiang W.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
语种: 英语
中文关键词: Dysbiosis ; IL-18 ; Immune system ; Inflammasome
英文关键词: Cell death ; Enzymes ; Mammals ; Physiology ; Cell loss ; Disease progression ; Dysbiosis ; Gut microbiota ; Homoeostasis ; Immune cells ; Inflammasome ; Interleukin-18 ; Microbiotas ; Small intestine ; Immune system
英文摘要: Inflammasomes and their product interleukin 18 (IL-18) play important roles in gut microbiota monitoring and homeostasis, and their loss of function could lead to microbiota dysbiosis and accelerate disease progression. However, the impacts of the resulting microbiota dysbiosis on the mucosal immune system are largely unknown. Here, we show that dysbiotic microbiota from Il18−/− mice induced immune cell loss in the small intestine (SI) in an inflammasome-independent manner. Cohousing experiments revealed that the immunotoxic phenotype of these microbiota was transferable to wild type (WT) mice and induced immune cell death through the receptor-interacting protein kinase 3 (RIP3)-mixed lineage kinase domain like pseudokinase (MLKL) pathway. Analysis of microbiota composition identified two types of bacteria at the genus level, Ureaplasma and Parasutterella, that accumulated in Il18−/− mice and negatively mediated changes in immune cells in the SI. Furthermore, dysbiosis in Il18−/− mice also contributed to increased susceptibility to Listeria infection. Collectively, our results demonstrate that IL-18 is essential to microbiota homeostasis and that dysbiotic microbiota could significantly shape the landscape of the immune system. © 2021 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170526
Appears in Collections:气候变化与战略

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作者单位: Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China; The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei, 230027, China

Recommended Citation:
Zheng X.,Liu L.,Meng G.,et al. IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota-dependent manner[J]. Science Bulletin,2021-01-01
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