globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2021.04.002
论文题名:
Single-cell atlas of domestic pig cerebral cortex and hypothalamus
作者: Zhu J.; Chen F.; Luo L.; Wu W.; Dai J.; Zhong J.; Lin X.; Chai C.; Ding P.; Liang L.; Wang S.; Ding X.; Chen Y.; Wang H.; Qiu J.; Wang F.; Sun C.; Zeng Y.; Fang J.; Jiang X.; Liu P.; Tang G.; Qiu X.; Zhang X.; Ruan Y.; Jiang S.; Li J.; Zhu S.; Xu X.; Li F.; Liu Z.; Cao G.; Chen D.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期:14
起始页码: 1448
结束页码: 1461
语种: 英语
中文关键词: Brain cell atlas ; Domestic pig ; Neural science ; Single-cell transcriptome
英文关键词: Cytology ; Gene expression ; Mammals ; Brain cell atlas ; Cellular composition ; Cerebral cortex ; Domestic pigs ; Frontal lobes ; Neural science ; Single cells ; Single-cell transcriptome ; Temporal lobes ; Transcriptomics ; Brain
英文摘要: The brain of the domestic pig (Sus scrofa domesticus) has drawn considerable attention due to its high similarities to that of humans. However, the cellular compositions of the pig brain (PB) remain elusive. Here we investigated the single-nucleus transcriptomic profiles of five regions of the PB (frontal lobe, parietal lobe, temporal lobe, occipital lobe, and hypothalamus) and identified 21 cell subpopulations. The cross-species comparison of mouse and pig hypothalamus revealed the shared and specific gene expression patterns at the single-cell resolution. Furthermore, we identified cell types and molecular pathways closely associated with neurological disorders, bridging the gap between gene mutations and pathogenesis. We reported, to our knowledge, the first single-cell atlas of domestic pig cerebral cortex and hypothalamus combined with a comprehensive analysis across species, providing extensive resources for future research regarding neural science, evolutionary developmental biology, and regenerative medicine. © 2021 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170530
Appears in Collections:气候变化与战略

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作者单位: College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China; BGI-Shenzhen, Shenzhen, 518083, China; MGI, BGI-Shenzhen, Shenzhen, 518083, China; Department of Neurobiology, NHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brian Medicine, and the MOE Frontier Science Center for Brain Research and Brain–Machine Integration, Zhejiang University School of Medicine, Hangzhou, 310031, China; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; School of Biological Science & Medical Engineering, Southeast University, Nanjing, 210096, China; School of Basic Medicine, Qingdao University, Qingdao, 266071, China; College of Life Science, South China Agricultural University, Guangzhou, 510642, China; Shenzhen Children's Hospital, Shenzhen, 518083, China; Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, 430070, China

Recommended Citation:
Zhu J.,Chen F.,Luo L.,et al. Single-cell atlas of domestic pig cerebral cortex and hypothalamus[J]. Science Bulletin,2021-01-01,66(14)
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