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globalchange > 过去全球变化的重建

DOI:	10.1371/journal.pone.0100474
论文题名:	In Situ Natural Product Discovery via an Artificial Marine Sponge
作者:	James J. La Clair; Steven T. Loveridge; Karen Tenney; Mark O'Neil–Johnson; Eli Chapman; Phillip Crews
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2014
发表日期:	2014-7-8
卷:	9, 期:7
语种:	英语
英文关键词:	Sponges ; NMR spectroscopy ; Protons ; Marine biology ; Sea water ; Marine environments ; Marine ecosystems ; Marine chemistry
英文摘要:	There is continuing international interest in exploring and developing the therapeutic potential of marine–derived small molecules. Balancing the strategies for ocean based sampling of source organisms versus the potential to endanger fragile ecosystems poses a substantial challenge. In order to mitigate such environmental impacts, we have developed a deployable artificial sponge. This report provides details on its design followed by evidence that it faithfully recapitulates traditional natural product collection protocols. Retrieving this artificial sponge from a tropical ecosystem after deployment for 320 hours afforded three actin–targeting jasplakinolide depsipeptides that had been discovered two decades earlier using traditional sponge specimen collection and isolation procedures. The successful outcome achieved here could reinvigorate marine natural products research, by producing new environmentally innocuous sources of natural products and providing a means to probe the true biosynthetic origins of complex marine–derived scaffolds.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100474&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/18347
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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File Name/ File Size	Content Type	Version	Access	License
10.1371journal.pone.0100474.PDF（1040KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Xenobe Research Institute, San Diego, California, United States of America;Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, United States of America;Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, United States of America;Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., St. Louis, Missouri, United States of America;Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, United States of America;Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, United States of America

Recommended Citation:

James J. La Clair,Steven T. Loveridge,Karen Tenney,et al. In Situ Natural Product Discovery via an Artificial Marine Sponge[J]. PLOS ONE,2014-01-01,9(7)

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