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globalchange > 过去全球变化的重建

DOI:	10.1371/journal.pone.0112128
论文题名:	Elucidation of the Interaction Mechanism with Liposomes of gH625-Peptide Functionalized Dendrimers
作者:	Annarita Falanga; Rossella Tarallo; Thomas Carberry; Massimiliano Galdiero; Marcus Weck; Stefania Galdiero
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2014
发表日期:	2014-11-25
卷:	9, 期:11
语种:	英语
英文关键词:	Lipids ; Tryptophan ; Cell membranes ; Isotherms ; Drug delivery ; Liposomes ; Vesicles ; Isothermal titration calorimetry
英文摘要:	We have demonstrated that amide-based dendrimers functionalized with the membrane-interacting peptide gH625 derived from the herpes simplex virus type 1 (HSV-1) envelope glycoprotein H enter cells mainly through a non-active translocation mechanism. Herein, we investigate the interaction between the peptide-functionalized dendrimer and liposomes composed of PC/Chol using fluorescence spectroscopy, isothermal titration calorimetry, and surface plasmon resonance to get insights into the mechanism of internalization. The affinity for the membrane bilayer is very high and the interaction between the peptide-dendrimer and liposomes took place without evidence of pore formation. These results suggest that the presented peptidodendrimeric scaffold may be a promising material for efficient drug delivery.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112128&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/18465
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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journal.pone.0112128.PDF（1012KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Department of Pharmacy & CIRPEB & DFM Scarl, University of Naples “Federico II”, Naples, Italy;Molecular Design Institute and Department of Chemistry, New York University, New York, New York, United States of America;Molecular Design Institute and Department of Chemistry, New York University, New York, New York, United States of America;Department of Experimental Medicine, Second University of Naples, Naples, Italy;Molecular Design Institute and Department of Chemistry, New York University, New York, New York, United States of America;Department of Pharmacy & CIRPEB & DFM Scarl, University of Naples “Federico II”, Naples, Italy

Recommended Citation:

Annarita Falanga,Rossella Tarallo,Thomas Carberry,et al. Elucidation of the Interaction Mechanism with Liposomes of gH625-Peptide Functionalized Dendrimers[J]. PLOS ONE,2014-01-01,9(11)

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