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DOI: 10.1371/journal.pone.0110166
论文题名:
Prolonged Seasonality of Respiratory Syncytial Virus Infection among Preterm Infants in a Subtropical Climate
作者: Chyong-Hsin Hsu; Chia-Ying Lin; Hsin Chi; Jui-Hsing Chang; Han-Yang Hung; Hsin-An Kao; Chun-Chih Peng; Wai-Tim Jim
刊名: PLOS ONE
ISSN: 1932-6203
出版年: 2014
发表日期: 2014-10-21
卷: 9, 期:10
语种: 英语
英文关键词: Infants ; Respiratory infections ; Taiwan ; Seasons ; Respiratory syncytial virus infection ; Birth weight ; Children ; Pediatric infections
英文摘要: Objective There is limited epidemiological data on the seasonality of respiratory syncytial virus (RSV) infection in subtropical climates, such as in Taiwan. This study aimed to assess RSV seasonality among children ≤24 months of age in Taiwan. We also assessed factors (gestational age [GA], chronologic age [CA], and bronchopulmonary dysplasia [BPD]) associated with RSV-associated hospitalization in preterm infants to confirm the appropriateness of the novel Taiwanese RSV prophylactic policy. Study Design From January 2000 to August 2010, 3572 children aged ≤24-months were admitted to Taipei Mackay Memorial Hospital due to RSV infection. The monthly RSV-associated hospitalization rate among children aged ≤24 months was retrospectively reviewed. Among these children, 378 were born preterm. The associations between GA, CA, and BPD and the incidence of RSV-associated hospitalization in the preterm infants were assessed. Results In children aged ≤24 months, the monthly distribution of RSV-associated hospitalization rates revealed a prolonged RSV season with a duration of 10 months. Infants with GAs ≤32 weeks and those who had BPD had the highest rates of RSV hospitalization (P<0.001). Preterm infants were most vulnerable to RSV infection within CA 9 months. Conclusions Given that Taiwan has a prolonged (10-month) RSV season, the American Academy of Pediatrics' recommendations for RSV prophylaxis are not directly applicable. The current Taiwanese guidelines for RSV prophylaxis, which specify palivizumab injection (a total six doses until CA 8–9 months) for preterm infants (those born before 286/7 weeks GA or before 356/7 weeks GA with BPD), are appropriate. This prophylaxis strategy may be applicable to other countries/regions with subtropical climates.
URL: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0110166&type=printable
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/18523
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

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作者单位: Department of Pediatrics, Division of Neonatology, Mackay Memorial Hospital, Taipei, Taiwan;Department of Pediatrics, Division of Neonatology, Mackay Memorial Hospital, Taipei, Taiwan;Department of Pediatrics, Division of Infectious Disease, Mackay Memorial Hospital, Taipei, Taiwan;Department of Pediatrics, Division of Neonatology, Mackay Memorial Hospital, Taipei, Taiwan;Department of Pediatrics, Division of Neonatology, Mackay Memorial Hospital, Taipei, Taiwan;Department of Pediatrics, Division of Neonatology, Mackay Memorial Hospital, Taipei, Taiwan;Department of Pediatrics, Division of Neonatology, Mackay Memorial Hospital, Taipei, Taiwan;Department of Pediatrics, Division of Neonatology, Mackay Memorial Hospital, Taipei, Taiwan

Recommended Citation:
Chyong-Hsin Hsu,Chia-Ying Lin,Hsin Chi,et al. Prolonged Seasonality of Respiratory Syncytial Virus Infection among Preterm Infants in a Subtropical Climate[J]. PLOS ONE,2014-01-01,9(10)
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