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globalchange > 过去全球变化的重建

DOI:	10.1371/journal.pone.0092068
论文题名:	Tracking of Magnetite Labeled Nanoparticles in the Rat Brain Using MRI
作者:	Naira P. Martínez Vera; Reinhold Schmidt; Klaus Langer; Iavor Zlatev; Robert Wronski; Ewald Auer; Daniel Havas; Manfred Windisch; Hagen von Briesen; Sylvia Wagner; Julia Stab; Motti Deutsch; Claus Pietrzik; Franz Fazekas; Stefan Ropele
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2014
发表日期:	2014-3-14
卷:	9, 期:3
语种:	英语
英文关键词:	Magnetite ; Nanoparticles ; Magnetic resonance imaging ; NMR relaxation ; Fluorescence imaging ; Prussian blue staining ; Central nervous system ; Body temperature
英文摘要:	This study was performed to explore the feasibility of tracing nanoparticles for drug transport in the healthy rat brain with a clinical MRI scanner. Phantom studies were performed to assess the R1 ( = 1/T1) relaxivity of different magnetically labeled nanoparticle (MLNP) formulations that were based on biodegradable human serum albumin and that were labeled with magnetite of different size. In vivo MRI measurements in 26 rats were done at 3T to study the effect and dynamics of MLNP uptake in the rat brain and body. In the brain, MLNPs induced T1 changes were quantitatively assessed by T1 relaxation time mapping in vivo and compared to post-mortem results from fluorescence imaging. Following intravenous injection of MLNPs, a visible MLNP uptake was seen in the liver and spleen while no visual effect was seen in the brain. However a histogram analysis of T1 changes in the brain demonstrated global and diffuse presence of MLNPs. The magnitude of these T1 changes scaled with post-mortem fluorescence intensity. This study demonstrates the feasibility of tracking even small amounts of magnetite labeled NPs with a sensitive histogram technique in the brain of a living rodent.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092068&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/18850
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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File Name/ File Size	Content Type	Version	Access	License
journal.pone.0092068.PDF（1297KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Department of Neurology, Medical University of Graz, Graz, Austria;Department of Neurology, Medical University of Graz, Graz, Austria;Institute of Pharmaceutical Technology and Biopharmacy, University of Muenster, Muenster, Germany;Institute of Pharmaceutical Technology and Biopharmacy, University of Muenster, Muenster, Germany;JSW-Live Sciences GmbH, Grambach, Austria;JSW-Live Sciences GmbH, Grambach, Austria;JSW-Live Sciences GmbH, Grambach, Austria;JSW-Live Sciences GmbH, Grambach, Austria;Department of Cell Biology & Applied Virology, Fraunhofer Institute for Biomedical Engineering, St. Ingbert, Germany;Department of Cell Biology & Applied Virology, Fraunhofer Institute for Biomedical Engineering, St. Ingbert, Germany;Department of Cell Biology & Applied Virology, Fraunhofer Institute for Biomedical Engineering, St. Ingbert, Germany;Physics Department, Schottenstein Center for the Research and Technology of the Cellome, Bar Ilan University, Ramat Gan, Israel;Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany;Department of Neurology, Medical University of Graz, Graz, Austria;Department of Neurology, Medical University of Graz, Graz, Austria

Recommended Citation:

Naira P. Martínez Vera,Reinhold Schmidt,Klaus Langer,et al. Tracking of Magnetite Labeled Nanoparticles in the Rat Brain Using MRI[J]. PLOS ONE,2014-01-01,9(3)

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