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DOI:	10.1371/journal.pone.0086084
论文题名:	Cadherin-23 May Be Dynamic in Hair Bundles of the Model Sea Anemone Nematostella vectensis
作者:	Pei-Ciao Tang; Glen M. Watson
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2014
发表日期:	2014-1-22
卷:	9, 期:1
语种:	英语
英文关键词:	Sea anemones ; Vibration ; Sea water ; Fluorescence imaging ; Polypeptides ; Immunocytochemistry ; Cadherins ; Cell membranes
英文摘要:	Cadherin 23 (CDH23), a component of tip links in hair cells of vertebrate animals, is essential to mechanotransduction by hair cells in the inner ear. A homolog of CDH23 occurs in hair bundles of sea anemones. Anemone hair bundles are located on the tentacles where they detect the swimming movements of nearby prey. The anemone CDH23 is predicted to be a large polypeptide featuring a short exoplasmic C-terminal domain that is unique to sea anemones. Experimentally masking this domain with antibodies or mimicking this domain with free peptide rapidly disrupts mechanotransduction and morphology of anemone hair bundles. The loss of normal morphology is accompanied, or followed by a decrease in F-actin in stereocilia of the hair bundles. These effects were observed at very low concentrations of the reagents, 0.1–10 nM, and within minutes of exposure. The results presented herein suggest that: (1) the interaction between CDH23 and molecular partners on stereocilia of hair bundles is dynamic and; (2) the interaction is crucial for normal mechanotransduction and morphology of hair bundles.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0086084&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/18953
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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File Name/ File Size	Content Type	Version	Access	License
journal.pone.0086084.PDF（1188KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View 联系获取全文

作者单位:

Department of Biology, University of Louisiana at Lafayette, Lafayette, Louisiana, United States of America;Department of Biology, University of Louisiana at Lafayette, Lafayette, Louisiana, United States of America

Recommended Citation:

Pei-Ciao Tang,Glen M. Watson. Cadherin-23 May Be Dynamic in Hair Bundles of the Model Sea Anemone Nematostella vectensis[J]. PLOS ONE,2014-01-01,9(1)

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