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globalchange > 过去全球变化的重建

DOI:	10.1371/journal.pone.0102669
论文题名:	Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography
作者:	Manabu Kashiwagi; Linbo Liu; Kengyeh K. Chu; Chen-Hsin Sun; Atsushi Tanaka; Joseph A. Gardecki; Guillermo J. Tearney
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2014
发表日期:	2014-7-21
卷:	9, 期:7
语种:	英语
英文关键词:	Macrophages ; Crystals ; Cholesterol ; Coronary arteries ; Cytoplasmic inclusions ; Polarized light microscopy ; Crystalline inclusions ; Tomography
英文摘要:	The presence of cholesterol crystals is a hallmark of atherosclerosis, but until recently, such crystals have been considered to be passive components of necrotic plaque cores. Recent studies have demonstrated that phagocytosis of cholesterol crystals by macrophages may actively precipitate plaque progression via an inflammatory pathway, emphasizing the need for methods to study the interaction between macrophages and crystalline cholesterol. In this study, we demonstrate the feasibility of detecting cholesterol in macrophages in situ using Micro-Optical Coherence Tomography (µOCT), an imaging modality we have recently developed with 1-µm resolution. Macrophages containing cholesterol crystals frequently demonstrated highly scattering constituents in their cytoplasm on µOCT imaging, and µOCT was able to evaluate cholesterol crystals in cultured macrophage cells. Our results suggest that µOCT may be useful for the detection and characterization of inflammatory activity associated with cholesterol crystals in the coronary artery.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0102669&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/19074
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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作者单位:

Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America;School of Electrical & Electronic Engineering and School of Chemical & Biomedical Engineering, Nanyang Technological University, Singapore, Singapore;Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America;Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America;Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America;Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America;Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America;Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America;Department of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America

Recommended Citation:

Manabu Kashiwagi,Linbo Liu,Kengyeh K. Chu,et al. Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography[J]. PLOS ONE,2014-01-01,9(7)

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