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DOI:	10.1371/journal.pone.0090399
论文题名:	TWEAK Promotes Peritoneal Inflammation
作者:	Ana Belen Sanz; Luiz Stark Aroeira; Teresa Bellon; Gloria del Peso; Jose Jimenez-Heffernan; Beatriz Santamaria; Maria Dolores Sanchez-Niño; Luis Miguel Blanco-Colio; Manuel Lopez-Cabrera; Marta Ruiz-Ortega; Jesus Egido; Rafael Selgas; Alberto Ortiz
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2014
发表日期:	2014-3-5
卷:	9, 期:3
语种:	英语
英文关键词:	Inflammation ; Peritonitis ; Effluent ; Macrophages ; Biopsy ; Fibrosis ; Neutrophils ; Inflammatory diseases
英文摘要:	Peritoneal dialysis (PD) is complicated by peritonitis episodes that cause loss of mesothelium and eventually sclerosing peritonitis. An improved understanding of the molecular contributors to peritoneal injury and defense may increase the therapeutic armamentarium to optimize peritoneal defenses while minimizing peritoneal injury. There is no information on the expression and function of the cytokine TWEAK and its receptor Fn14 during peritoneal injury. Fn14 expression and soluble TWEAK levels were measured in human PD peritoneal effluent cells or fluids with or without peritonitis. Fn14 expression was also analyzed in peritoneal biopsies from PD patients. Actions of intraperitoneal TWEAK were studied in mice in vivo. sTWEAK levels were increased in peritoneal effluent in PD peritonitis. Effluent sTWEAK levels correlated with the number of peritoneal macrophages (r = 0.491, p = 0.002). Potential TWEAK targets that express the receptor Fn14 include mesothelial cells and macrophages, as demonstrated by flow cytometry of peritoneal effluents and by analysis of peritoneal biopsies. Peritoneal biopsy Fn14 correlated with mesothelial injury, fibrosis and inflammation, suggesting a potential deleterious effect of TWEAK/Fn14. In this regard, intraperitoneal TWEAK administration to mice promoted peritoneal inflammation characterized by increased peritoneal effluent MCP-1, Fn14 and Gr1+ macrophages, increased mesothelial Fn14, MCP-1 and CCL21 expression and submesothelial tissue macrophage recruitment. Taken together these data suggest that the TWEAK/Fn14 system may promote inflammation and tissue injury during peritonitis and PD.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090399&type=printable
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资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/19259
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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作者单位:

Laboratory of Nephrology, IIS-Fundacion Jimenez Diaz, Madrid, Spain;REDinREN, Madrid, Spain;Department of Immunology, Instituto de Investigación Biomédica de Vigo (IBIV), Vigo, Pontevedra, Spain;Department of Nephrology, IDIPAZ, Madrid, Spain;Department of Nephrology, IDIPAZ, Madrid, Spain;REDinREN, Madrid, Spain;Hospital Universitario de la Princesa, Madrid, Spain;Laboratory of Nephrology, IIS-Fundacion Jimenez Diaz, Madrid, Spain;Department of Nephrology, IDIPAZ, Madrid, Spain;REDinREN, Madrid, Spain;Laboratory of Nephrology, IIS-Fundacion Jimenez Diaz, Madrid, Spain;REDinREN, Madrid, Spain;Centro Biologia Molecular Severo Ochoa, Madrid, Spain;Laboratory of Nephrology, IIS-Fundacion Jimenez Diaz, Madrid, Spain;REDinREN, Madrid, Spain;Universidad Autonoma de Madrid, Madrid, Spain;Laboratory of Nephrology, IIS-Fundacion Jimenez Diaz, Madrid, Spain;Universidad Autonoma de Madrid, Madrid, Spain;IRSIN, Madrid, Spain;Department of Nephrology, IDIPAZ, Madrid, Spain;REDinREN, Madrid, Spain;Universidad Autonoma de Madrid, Madrid, Spain;IRSIN, Madrid, Spain;Laboratory of Nephrology, IIS-Fundacion Jimenez Diaz, Madrid, Spain;REDinREN, Madrid, Spain;Universidad Autonoma de Madrid, Madrid, Spain;IRSIN, Madrid, Spain

Recommended Citation:

Ana Belen Sanz,Luiz Stark Aroeira,Teresa Bellon,et al. TWEAK Promotes Peritoneal Inflammation[J]. PLOS ONE,2014-01-01,9(3)

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