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DOI:	10.1371/journal.pone.0088139
论文题名:	Methods to Assess the Impact of Mass Oral Cholera Vaccination Campaigns under Real Field Conditions
作者:	Jacqueline Deen; Mohammad Ali; David Sack
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2014
发表日期:	2014-2-7
卷:	9, 期:2
语种:	英语
英文关键词:	Cholera vaccines ; Cholera ; Vaccines ; Diarrhea ; Geographic information systems ; Vibrio cholerae ; Observational studies ; Neighborhoods
英文摘要:	There is increasing interest to use oral cholera vaccination as an additional strategy to water and sanitation interventions against endemic and epidemic cholera. There are two internationally-available and WHO-prequalified oral cholera vaccines: an inactivated vaccine containing killed whole-cells of V. cholerae O1 with recombinant cholera toxin B-subunit (WC/rBS) and a bivalent inactivated vaccine containing killed whole cells of V. cholerae O1 and V. cholerae O139 (BivWC). The efficacy, effectiveness, direct and indirect (herd) protection conferred by WC/rBS and BivWC are well established. Yet governments may need local evidence of vaccine impact to justify and scale-up mass oral cholera vaccination campaigns. We discuss various approaches to assess oral cholera vaccine protection, which may be useful to policymakers and public health workers considering deployment and evaluation of the vaccine.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0088139&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/19685
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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File Name/ File Size	Content Type	Version	Access	License
journal.pone.0088139.PDF（383KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Menzies School of Health Research, Casuarina, Northern Territory, Australia;Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America;Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

Recommended Citation:

Jacqueline Deen,Mohammad Ali,David Sack. Methods to Assess the Impact of Mass Oral Cholera Vaccination Campaigns under Real Field Conditions[J]. PLOS ONE,2014-01-01,9(2)

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