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DOI:	10.1371/journal.pone.0095737
论文题名:	Characterization and Function of the First Antibiotic Isolated from a Vent Organism: The Extremophile Metazoan Alvinella pompejana
作者:	Aurélie Tasiemski; Sascha Jung; Céline Boidin-Wichlacz; Didier Jollivet; Virginie Cuvillier-Hot; Florence Pradillon; Costantino Vetriani; Oliver Hecht; Frank D. Sönnichsen; Christoph Gelhaus; Chien-Wen Hung; Andreas Tholey; Matthias Leippe; Joachim Grötzinger; Françoise Gaill
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2014
发表日期:	2014-4-28
卷:	9, 期:4
语种:	英语
英文关键词:	Bacteria ; Hydrothermal vents ; Annelids ; Peptides ; Symbiosis ; Archaean biology ; Protein structure comparison ; NMR spectroscopy
英文摘要:	The emblematic hydrothermal worm Alvinella pompejana is one of the most thermo tolerant animal known on Earth. It relies on a symbiotic association offering a unique opportunity to discover biochemical adaptations that allow animals to thrive in such a hostile habitat. Here, by studying the Pompeii worm, we report on the discovery of the first antibiotic peptide from a deep-sea organism, namely alvinellacin. After purification and peptide sequencing, both the gene and the peptide tertiary structures were elucidated. As epibionts are not cultivated so far and because of lethal decompression effects upon Alvinella sampling, we developed shipboard biological assays to demonstrate that in addition to act in the first line of defense against microbial invasion, alvinellacin shapes and controls the worm's epibiotic microflora. Our results provide insights into the nature of an abyssal antimicrobial peptide (AMP) and into the manner in which an extremophile eukaryote uses it to interact with the particular microbial community of the hydrothermal vent ecosystem. Unlike earlier studies done on hydrothermal vents that all focused on the microbial side of the symbiosis, our work gives a view of this interaction from the host side.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095737&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/19882
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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File Name/ File Size	Content Type	Version	Access	License
journal.pone.0095737.PDF（1324KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Université de Lille1-CNRS UMR8198, Laboratoire GEPV, Ecoimmunology of Marine Annelids (EMA), Villeneuve d'Ascq, France;Institute of Biochemistry, Christian-Albrechts-Universität, Kiel, Germany;Université de Lille1-CNRS UMR8198, Laboratoire GEPV, Ecoimmunology of Marine Annelids (EMA), Villeneuve d'Ascq, France;Université Pierre et Marie Curie-CNRS UMR7144, Laboratoire AD2M, Adaptation et Biologie des Invertébrés en Conditions Extrêmes (ABICE), Station Biologique, Roscoff, France;Université de Lille1-CNRS UMR8198, Laboratoire GEPV, Ecoimmunology of Marine Annelids (EMA), Villeneuve d'Ascq, France;IFREMER, Centre de Brest, REM/EEP/LEP, Plouzané, France;Department of Biochemistry and Microbiology and Institute of Marine and Coastal Sciences, Rutgers University, New Brunswick, New Jersey, United States of America;Institute of Biochemistry, Christian-Albrechts-Universität, Kiel, Germany;Otto Diels Institute for Organic Chemistry, Christian-Albrechts-Universität, Kiel, Germany;Institute of Zoology, Zoophysiology, Christian-Albrechts-Universität, Kiel, Germany;Division of Systematic Proteome Research, Institute for Experimental Medicine, Christian-Albrechts-Universität, Kiel, Germany;Division of Systematic Proteome Research, Institute for Experimental Medicine, Christian-Albrechts-Universität, Kiel, Germany;Institute of Zoology, Zoophysiology, Christian-Albrechts-Universität, Kiel, Germany;Institute of Biochemistry, Christian-Albrechts-Universität, Kiel, Germany;Université Pierre et Marie Curie-Muséum National d'Histoires Naturelles CNRS BOREA IRD, Paris, France

Recommended Citation:

Aurélie Tasiemski,Sascha Jung,Céline Boidin-Wichlacz,et al. Characterization and Function of the First Antibiotic Isolated from a Vent Organism: The Extremophile Metazoan Alvinella pompejana[J]. PLOS ONE,2014-01-01,9(4)

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