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DOI:	10.1371/journal.pone.0095590
论文题名:	Biological Characteristics of the MG-63 Human Osteosarcoma Cells on Composite Tantalum Carbide/Amorphous Carbon Films
作者:	Yin-Yu Chang; Heng-Li Huang; Ya-Chi Chen; Jui-Ting Hsu; Tzong-Ming Shieh; Ming-Tzu Tsai
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2014
发表日期:	2014-4-23
卷:	9, 期:4
语种:	英语
英文关键词:	Coatings ; Cathodes ; Fluorescence imaging ; Fluorescence microscopy ; Graphite ; Medical devices and equipment ; Tantalum ; X-ray photoelectron spectroscopy
英文摘要:	Tantalum (Ta) is a promising metal for biomedical implants or implant coating for orthopedic and dental applications because of its excellent corrosion resistance, fracture toughness, and biocompatibility. This study synthesizes biocompatible tantalum carbide (TaC) and TaC/amorphous carbon (a-C) coatings with different carbon contents by using a twin-gun magnetron sputtering system to improve their biological properties and explore potential surgical implant or device applications. The carbon content in the deposited coatings was regulated by controlling the magnetron power ratio of the pure graphite and Ta cathodes. The deposited TaC and TaC/a-C coatings exhibited better cell viability of human osteosarcoma cell line MG-63 than the uncoated Ti and Ta-coated samples. Inverted optical and confocal imaging was used to demonstrate the cell adhesion, distribution, and proliferation of each sample at different time points during the whole culture period. The results show that the TaC/a-C coating, which contained two metastable phases (TaC and a-C), was more biocompatible with MG-63 cells compared to the pure Ta coating. This suggests that the TaC/a-C coatings exhibit a better biocompatible performance for MG-63 cells, and they may improve implant osseointegration in clinics.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095590&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/19884
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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journal.pone.0095590.PDF（2643KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Department of Mechanical and Computer-Aided Engineering, National Formosa University, Yunlin, Taiwan;School of Dentistry, China Medical University, Taichung, Taiwan;Department of Materials Science and Engineering, Mingdao University, Changhua, Taiwan;School of Dentistry, China Medical University, Taichung, Taiwan;Department of Dental Hygiene, China Medical University, Taichung, Taiwan;Department of Biomedical Engineering, Hungkuang University, Taichung, Taiwan

Recommended Citation:

Yin-Yu Chang,Heng-Li Huang,Ya-Chi Chen,et al. Biological Characteristics of the MG-63 Human Osteosarcoma Cells on Composite Tantalum Carbide/Amorphous Carbon Films[J]. PLOS ONE,2014-01-01,9(4)

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