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DOI: 10.1371/journal.pone.0088119
论文题名:
Quantifying Significance of Topographical Similarities of Disease-Related Brain Metabolic Patterns
作者: Ji Hyun Ko; Phoebe Spetsieris; Yilong Ma; Vijay Dhawan; David Eidelberg
刊名: PLOS ONE
ISSN: 1932-6203
出版年: 2014
发表日期: 2014-1-31
卷: 9, 期:1
语种: 英语
英文关键词: Covariance ; Neural networks ; Parkinson disease ; Permutation ; South Korea ; Spatial autocorrelation ; Brain diseases ; Neuroimaging
英文摘要: Multivariate analytical routines have become increasingly popular in the study of cerebral function in health and in disease states. Spatial covariance analysis of functional neuroimaging data has been used to identify and validate characteristic topographies associated with specific brain disorders. Voxel-wise correlations can be used to assess similarities and differences that exist between covariance topographies. While the magnitude of the resulting topographical correlations is critical, statistical significance can be difficult to determine in the setting of large data vectors (comprised of over 100,000 voxel weights) and substantial autocorrelation effects. Here, we propose a novel method to determine the p-value of such correlations using pseudo-random network simulations.
URL: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0088119&type=printable
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/19938
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

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作者单位: Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America;Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America;Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America;Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America;Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America

Recommended Citation:
Ji Hyun Ko,Phoebe Spetsieris,Yilong Ma,et al. Quantifying Significance of Topographical Similarities of Disease-Related Brain Metabolic Patterns[J]. PLOS ONE,2014-01-01,9(1)
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