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DOI:	10.1371/journal.pone.0084714
论文题名:	Loss of Olfactory Receptor Function in Hominin Evolution
作者:	Graham M. Hughes; Emma C. Teeling; Desmond G. Higgins
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2014
发表日期:	2014-1-2
卷:	9, 期:1
语种:	英语
英文关键词:	Paleoanthropology ; Neanderthals ; Paleogenetics ; Genomic databases ; Pseudogenes ; Hominins ; Extinct genomes ; Comparative genomics
英文摘要:	The mammalian sense of smell is governed by the largest gene family, which encodes the olfactory receptors (ORs). The gain and loss of OR genes is typically correlated with adaptations to various ecological niches. Modern humans have 853 OR genes but 55% of these have lost their function. Here we show evidence of additional OR loss of function in the Neanderthal and Denisovan hominin genomes using comparative genomic methodologies. Ten Neanderthal and 8 Denisovan ORs show evidence of loss of function that differ from the reference modern human OR genome. Some of these losses are also present in a subset of modern humans, while some are unique to each lineage. Morphological changes in the cranium of Neanderthals suggest different sensory arrangements to that of modern humans. We identify differences in functional olfactory receptor genes among modern humans, Neanderthals and Denisovans, suggesting varied loss of function across all three taxa and we highlight the utility of using genomic information to elucidate the sensory niches of extinct species.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0084714&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/19955
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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File Name/ File Size	Content Type	Version	Access	License
journal.pone.0084714.PDF（1277KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

UCD School of Biology and Environmental Science, University College Dublin, Belfield, Dublin, Ireland;UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland;UCD School of Biology and Environmental Science, University College Dublin, Belfield, Dublin, Ireland;UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland

Recommended Citation:

Graham M. Hughes,Emma C. Teeling,Desmond G. Higgins. Loss of Olfactory Receptor Function in Hominin Evolution[J]. PLOS ONE,2014-01-01,9(1)

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