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DOI:	10.1371/journal.pone.0106846
论文题名:	Seasonality Modifies Methylation Profiles in Healthy People
作者:	Fulvio Ricceri; Morena Trevisan; Valentina Fiano; Chiara Grasso; Francesca Fasanelli; Chiara Scoccianti; Laura De Marco; Anna Gillio Tos; Paolo Vineis; Carlotta Sacerdote
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2014
发表日期:	2014-9-11
卷:	9, 期:9
语种:	英语
英文关键词:	DNA methylation ; Seasons ; Epigenetics ; Air pollution ; Summer ; Gene expression ; Gene regulation ; Polymerase chain reaction
英文摘要:	DNA methylation is a well-characterized epigenetic modification that plays an important role in the regulation of gene expression. There is growing evidence on the involvement of epigenetic mechanisms in disease onset, including cancer. Environmental factors seem to induce changes in DNA methylation affecting human health. However, little is known about basal methylation levels in healthy people and about the correlation between environmental factors and different methylation profiles. We investigated the effect of seasonality on basal methylation by testing methylation levels in the long interspersed nucleotide element-1 (LINE-1) and in two cancer-related genes (RASSF1A and MGMT) of 88 healthy male heavy smokers involved in an Italian randomized study; at enrolment the subjects donated a blood sample collected in different months. Methylation analyses were performed by pyrosequencing. Mean methylation percentage was higher in spring and summer for the LINE1, RASSF1A and MGMT genes (68.26%, 2.35%, and 9.52% respectively) compared with autumn and winter (67.43%, 2.17%, and 8.60% respectively). In particular, LINE-1 was significantly hypomethylated (p = 0.04 or 0.05 depending on the CpG island involved) in autumn and winter compared with spring and summer. Seasonality seems to be a modifier of methylation levels and this observation should be taken into account in future analyses.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0106846&type=printable
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资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/19990
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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作者单位:

Unit of Cancer Epidemiology – CERMS, Department of Medical Sciences, University of Turin and Città della Salute e della Scienza Hospital, Turin, Italy;Department of Mathematics, University of Turin, Turin, Italy;Unit of Cancer Epidemiology – CERMS, Department of Medical Sciences, University of Turin and Città della Salute e della Scienza Hospital, Turin, Italy;Unit of Cancer Epidemiology – CERMS, Department of Medical Sciences, University of Turin and Città della Salute e della Scienza Hospital, Turin, Italy;Unit of Cancer Epidemiology – CERMS, Department of Medical Sciences, University of Turin and Città della Salute e della Scienza Hospital, Turin, Italy;Unit of Cancer Epidemiology – CERMS, Department of Medical Sciences, University of Turin and Città della Salute e della Scienza Hospital, Turin, Italy;IARC, Lyon, France;Unit of Cancer Epidemiology – CERMS, Department of Medical Sciences, University of Turin and Città della Salute e della Scienza Hospital, Turin, Italy;Unit of Cancer Epidemiology – CERMS, Department of Medical Sciences, University of Turin and Città della Salute e della Scienza Hospital, Turin, Italy;Human Genetics Foundation (HUGEF), Turin, Italy;Imperial College, London, United Kingdom;Unit of Cancer Epidemiology – CERMS, Department of Medical Sciences, University of Turin and Città della Salute e della Scienza Hospital, Turin, Italy

Recommended Citation:

Fulvio Ricceri,Morena Trevisan,Valentina Fiano,et al. Seasonality Modifies Methylation Profiles in Healthy People[J]. PLOS ONE,2014-01-01,9(9)

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