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DOI:	10.1371/journal.pone.0132896
论文题名:	Comparative Analysis of Stress Induced Gene Expression in Caenorhabditis elegans following Exposure to Environmental and Lab Reconstituted Complex Metal Mixture
作者:	Ranjeet Kumar; Ajay Pradhan; Faisal Ahmad Khan; Pia Lindström; Daniel Ragnvaldsson; Per Ivarsson; Per-Erik Olsson; Jana Jass
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2015
发表日期:	2015-7-13
卷:	10, 期:7
语种:	英语
英文关键词:	Surface water ; Lakes ; Caenorhabditis elegans ; Heat shock response ; Toxicity ; Gene expression ; Oxidative stress ; Gene regulation
英文摘要:	Metals are essential for many physiological processes and are ubiquitously present in the environment. However, high metal concentrations can be harmful to organisms and lead to physiological stress and diseases. The accumulation of transition metals in the environment due to either natural processes or anthropogenic activities such as mining results in the contamination of water and soil environments. The present study used Caenorhabditis elegans to evaluate gene expression as an indicator of physiological response, following exposure to water collected from three different locations downstream of a Swedish mining site and a lab reconstituted metal mixture. Our results indicated that the reconstituted metal mixture exerted a direct stress response in C. elegans whereas the environmental waters elicited either a diminished or abrogated response. This suggests that it is not sufficient to use the biological effects observed from laboratory mixtures to extrapolate the effects observed in complex aquatic environments and apply this to risk assessment and intervention.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0132896&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/20855
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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File Name/ File Size	Content Type	Version	Access	License
journal.pone.0132896.PDF（3530KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

School of Science and Technology, The Life Science Center-Biology, Örebro University, Örebro, Sweden;School of Science and Technology, The Life Science Center-Biology, Örebro University, Örebro, Sweden;School of Science and Technology, The Life Science Center-Biology, Örebro University, Örebro, Sweden;Boliden Mineral AB, Boliden, Sweden;Envix Nord AB, Umeå, Sweden;ALS Scandinavia AB, Täby, Sweden;School of Science and Technology, The Life Science Center-Biology, Örebro University, Örebro, Sweden;School of Science and Technology, The Life Science Center-Biology, Örebro University, Örebro, Sweden

Recommended Citation:

Ranjeet Kumar,Ajay Pradhan,Faisal Ahmad Khan,et al. Comparative Analysis of Stress Induced Gene Expression in Caenorhabditis elegans following Exposure to Environmental and Lab Reconstituted Complex Metal Mixture[J]. PLOS ONE,2015-01-01,10(7)

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