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globalchange > 过去全球变化的重建

DOI:	10.1371/journal.pone.0129649
论文题名:	Seasonality of Pneumococcal Nasopharyngeal Carriage in Rural Gambia Determined within the Context of a Cluster Randomized Pneumococcal Vaccine Trial
作者:	Abdoulie Bojang; James Jafali; Uzochukwu E. Egere; Phillip C. Hill; Martin Antonio; David Jeffries; Brian M. Greenwood; Anna Roca
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2015
发表日期:	2015-7-1
卷:	10, 期:7
语种:	英语
英文关键词:	Seasons ; Age groups ; Vaccination and immunization ; Gambia ; Conjugate vaccines ; Pneumonia ; Pneumococcus ; Vaccines
英文摘要:	Background We conducted an ancillary study among individuals who had participated in a PCV-7 trial in rural Gambia, to determine the influence of season on the prevalence of pneumococcal carriage. Methods 636 individuals above 30 months of age were followed from 4 to 20 months after vaccination with PCV-7 or meningococcal-conjugate-vaccine. Nasopharyngeal swabs were collected periodically between November 2006 and June 2008. Overall, 4,495 NPS were collected. Results Prevalence of pneumococcal nasopharyngeal carriage in the study subjects (median age 11 years) was 55.0%; this prevalence decreased linearly with increasing age (p = 0.001). Prevalence of carriage was significantly higher during the dry than the rainy season for any pneumococcal carriage [57.6% versus 47.8% (p<0.001)], pneumococcal vaccine serotype carriage [10.3% versus 6.5% (p< 0.001)] and non-vaccine serotype carriage [49.7% versus 42.7% (p<0.001)]. Differences remained significant in the adjusted analysis. Conclusions In areas of Africa with marked variation in rainfall, seasonality of pneumococcal carriage needs to be considered when interpreting carriage data.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0129649&type=printable
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资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/21181
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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File Name/ File Size	Content Type	Version	Access	License
journal.pone.0129649.PDF（1200KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Medical Research Council Unit, Fajara, The Gambia;Medical Research Council Unit, Fajara, The Gambia;Medical Research Council Unit, Fajara, The Gambia;Medical Research Council Unit, Fajara, The Gambia;Centre for International Health, School of Medicine, University of Otago, Dunedin, New Zealand;Medical Research Council Unit, Fajara, The Gambia;Medical Research Council Unit, Fajara, The Gambia;Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom;Medical Research Council Unit, Fajara, The Gambia

Recommended Citation:

Abdoulie Bojang,James Jafali,Uzochukwu E. Egere,et al. Seasonality of Pneumococcal Nasopharyngeal Carriage in Rural Gambia Determined within the Context of a Cluster Randomized Pneumococcal Vaccine Trial[J]. PLOS ONE,2015-01-01,10(7)

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