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DOI:	10.1371/journal.pone.0119908
论文题名:	Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review
作者:	Vikki G. Nolan; Kerri A. Nottage; Elliott W. Cole; Jane S. Hankins; James G. Gurney
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2015
发表日期:	2015-3-3
卷:	10, 期:3
语种:	英语
英文关键词:	Vitamin D deficiency ; Vitamin D ; Micronutrient deficiencies ; African Americans ; Sickle cell disease ; Database searching ; Seasonal variations ; Systematic reviews
英文摘要:	Vitamin D deficiency has emerged as a public health focus in recent years and patients with sickle cell disease (SCD) reportedly have a high prevalence of the condition. Our objectives were to summarize definitions of vitamin D deficiency and insufficiency used in the literature, and to determine the prevalence and magnitude of each in patients with SCD through a systematic review conducted according to PRISMA guidelines. From a PubMed search, 34 potential articles were identified and 15 met eligibility criteria for inclusion. Definitions of deficiency and insufficiency varied greatly across studies making direct comparisons difficult. This review provides evidence to suggest that suboptimal vitamin D levels are highly prevalent among those with SCD, far more so than in comparable non-SCD patients or matched control populations. Defining deficiency as vitamin D <20ng/mL, prevalence estimates in SCD populations range from 56.4% to 96.4%. When compared with results from the population-based National Health and Nutrition Examination Survey, however, the general African American population appeared to have a similarly high prevalence of vitamin D deficiency. African American patients with and without SCD were both substantially higher than that of Caucasians. What remains to be determined is whether there are adverse health effects for patients with SCD because of concurrent vitamin D deficiency.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0119908&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/21406
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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journal.pone.0119908.PDF（749KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Departments of Hematology, Division of Epidemiology, Biostatistics and Environmental Health, University of Memphis, School of Public Health, Memphis, TN, United States of America;Epidemiology and Cancer Control, Division of Epidemiology, Biostatistics and Environmental Health, University of Memphis, School of Public Health, Memphis, TN, United States of America;Departments of Hematology, Division of Epidemiology, Biostatistics and Environmental Health, University of Memphis, School of Public Health, Memphis, TN, United States of America;Epidemiology and Cancer Control, Division of Epidemiology, Biostatistics and Environmental Health, University of Memphis, School of Public Health, Memphis, TN, United States of America;Departments of Hematology, Division of Epidemiology, Biostatistics and Environmental Health, University of Memphis, School of Public Health, Memphis, TN, United States of America;St. Jude Children’s Research Hospital, Memphis, TN, United States of America

Recommended Citation:

Vikki G. Nolan,Kerri A. Nottage,Elliott W. Cole,et al. Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review[J]. PLOS ONE,2015-01-01,10(3)

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