globalchange  > 过去全球变化的重建
DOI: 10.1371/journal.pone.0135687
论文题名:
Surveillance of Human Astrovirus Infection in Brazil: The First Report of MLB1 Astrovirus
作者: Maria da Penha Trindade Pinheiro Xavier; Filipe Aníbal Carvalho Costa; Mônica Simões Rocha; Juliana da Silva Ribeiro de Andrade; Fernanda Kreischer Bandeira Diniz; Thais Ramos de Andrade; Marize Pereira Miagostovich; José Paulo Gagliardi Leite; Eduardo de Mello Volotão
刊名: PLOS ONE
ISSN: 1932-6203
出版年: 2015
发表日期: 2015-8-14
卷: 10, 期:8
语种: 英语
英文关键词: Brazil ; Coastal regions ; DNA sequence analysis ; Phylogenetic analysis ; Astroviruses ; Sequence analysis ; Age groups ; Children
英文摘要: Human astrovirus (HAstV) represents the third most common virus associated with acute diarrhea (AD). This study aimed to estimate the prevalence of HAstV infection in Brazilian children under 5 years of age with AD, investigate the presence of recently described HAstV strains, through extensive laboratory-based surveillance of enteric viral agents in three Brazilian coastal regions between 2005 and 2011. Using reverse transcription-polymerase chain reaction (RT-PCR), the overall HAstV detection rate reached 7.1% (207/2.913) with percentage varying according to the geographic region: 3.9% (36/921) in the northeast, 7.9% in the south (71/903) and 9.2% in the southeast (100/1.089) (p < 0.001). HAstV were detected in cases of all age groups. Detection rates were slightly higher during the spring. Nucleotide sequence analysis of a 320-bp ORF2 fragment revealed that HAstV-1 was the predominant genotype throughout the seven years of the study. The novel AstV-MLB1 was detected in two children with AD from a subset of 200 samples tested, demonstrating the circulation of this virus both the in northeastern and southeastern regions of Brazil. These results provide additional epidemiological and molecular data on HAstV circulation in three Brazilian coastal regions, highlighting its potential to cause infantile AD.
URL: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0135687&type=printable
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/21530
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

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作者单位: Laboratory of Comparative and Environmental Virology—Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Ministry of Health, Rio de Janeiro, RJ, Brazil;Laboratory of Comparative and Environmental Virology—Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Ministry of Health, Rio de Janeiro, RJ, Brazil;Laboratory of Comparative and Environmental Virology—Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Ministry of Health, Rio de Janeiro, RJ, Brazil;Laboratory of Comparative and Environmental Virology—Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Ministry of Health, Rio de Janeiro, RJ, Brazil;Laboratory of Comparative and Environmental Virology—Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Ministry of Health, Rio de Janeiro, RJ, Brazil;Laboratory of Comparative and Environmental Virology—Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Ministry of Health, Rio de Janeiro, RJ, Brazil;Laboratory of Comparative and Environmental Virology—Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Ministry of Health, Rio de Janeiro, RJ, Brazil;Laboratory of Comparative and Environmental Virology—Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Ministry of Health, Rio de Janeiro, RJ, Brazil;Laboratory of Comparative and Environmental Virology—Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Ministry of Health, Rio de Janeiro, RJ, Brazil

Recommended Citation:
Maria da Penha Trindade Pinheiro Xavier,Filipe Aníbal Carvalho Costa,Mônica Simões Rocha,et al. Surveillance of Human Astrovirus Infection in Brazil: The First Report of MLB1 Astrovirus[J]. PLOS ONE,2015-01-01,10(8)
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