globalchange  > 过去全球变化的重建
DOI: 10.1371/journal.pone.0132533
论文题名:
Genogeography and Immune Epitope Characteristics of Hepatitis B Virus Genotype C Reveals Two Distinct Types: Asian and Papua-Pacific
作者: Meta Dewi Thedja; David Handojo Muljono; Susan Irawati Ie; Erick Sidarta; Turyadi; Jan Verhoef; Sangkot Marzuki
刊名: PLOS ONE
ISSN: 1932-6203
出版年: 2015
发表日期: 2015-7-10
卷: 10, 期:7
语种: 英语
英文关键词: Asia ; DNA sequence analysis ; Phylogeography ; Papua New Guinea ; Sequence analysis ; Geographic distribution ; Phylogenetic analysis ; Amino acid analysis
英文摘要: Distribution of hepatitis B virus (HBV) genotypes/subgenotypes is geographically and ethnologically specific. In the Indonesian archipelago, HBV genotype C (HBV/C) is prevalent with high genome variability, reflected by the presence of 13 of currently existing 16 subgenotypes. We investigated the association between HBV/C molecular characteristics with host ethnicity and geographical distribution by examining various subgenotypes of HBV/C isolates from the Asia and Pacific region, with further analysis on the immune epitope characteristics of the core and surface proteins. Phylogenetic tree was constructed based on complete HBV/C genome sequences from Asia and Pacific region, and genetic distance between isolates was also examined. HBV/C surface and core immune epitopes were analyzed and grouped by comparing the amino acid residue characteristics and geographical origins. Based on phylogenetic tree and geographical origins of isolates, two major groups of HBV/C isolates—East-Southeast Asia and Papua-Pacific—were identified. Analysis of core and surface immune epitopes supported these findings with several amino acid substitutions distinguishing the East-Southeast Asia isolates from the Papua-Pacific isolates. A west-to-east gradient of HBsAg subtype distribution was observed with adrq+ prominent in the East and Southeast Asia and adrq- in the Pacific, with several adrq-indeterminate subtypes observed in Papua and Papua New Guinea (PNG). This study indicates that HBV/C isolates can be classified into two types, the Asian and the Papua-Pacific, based on the virus genome diversity, immune epitope characteristics, and geographical distribution, with Papua and PNG as the molecular evolutionary admixture region in the switching from adrq+ to adrq-.
URL: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0132533&type=printable
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/21551
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

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作者单位: Eijkman Institute for Molecular Biology, Jakarta, Indonesia;Eijkman Winkler Institute, University Medical Centre (UMC) Utrecht, Utrecht, The Netherlands;Eijkman Institute for Molecular Biology, Jakarta, Indonesia;Faculty of Medicine, Hasanuddin University, Makassar, Indonesia;Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia;Eijkman Institute for Molecular Biology, Jakarta, Indonesia;Eijkman Institute for Molecular Biology, Jakarta, Indonesia;Eijkman Institute for Molecular Biology, Jakarta, Indonesia;Eijkman Winkler Institute, University Medical Centre (UMC) Utrecht, Utrecht, The Netherlands;Eijkman Institute for Molecular Biology, Jakarta, Indonesia;Department of Medicine, Monash Medical Centre, Monash University, Clayton, Victoria, Australia

Recommended Citation:
Meta Dewi Thedja,David Handojo Muljono,Susan Irawati Ie,et al. Genogeography and Immune Epitope Characteristics of Hepatitis B Virus Genotype C Reveals Two Distinct Types: Asian and Papua-Pacific[J]. PLOS ONE,2015-01-01,10(7)
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