globalchange  > 过去全球变化的重建
DOI: 10.1371/journal.pone.0134699
论文题名:
Whole Genome-Sequencing and Phylogenetic Analysis of a Historical Collection of Bacillus anthracis Strains from Danish Cattle
作者: Sylviane Derzelle; Guillaume Girault; Branko Kokotovic; Øystein Angen
刊名: PLOS ONE
ISSN: 1932-6203
出版年: 2015
发表日期: 2015-8-28
卷: 10, 期:8
语种: 英语
英文关键词: Phylogenetic analysis ; Bacillus anthracis ; Anthrax ; Phylogeography ; Comparative genomics ; Phylogenetics ; Genome sequencing ; Melting
英文摘要: Bacillus anthracis, the causative agent of anthrax, is known as one of the most genetically monomorphic species. Canonical single-nucleotide polymorphism (SNP) typing and whole-genome sequencing were used to investigate the molecular diversity of eleven B. anthracis strains isolated from cattle in Denmark between 1935 and 1988. Danish strains were assigned into five canSNP groups or lineages, i.e. A.Br.001/002 (n = 4), A.Br.Ames (n = 2), A.Br.008/011 (n = 2), A.Br.005/006 (n = 2) and A.Br.Aust94 (n = 1). The match with the A.Br.Ames lineage is of particular interest as the occurrence of such lineage in Europe is demonstrated for the first time, filling an historical gap within the phylogeography of the lineage. Comparative genome analyses of these strains with 41 isolates from other parts of the world revealed that the two Danish A.Br.008/011 strains were related to the heroin-associated strains responsible for outbreaks of injection anthrax in drug users in Europe. Eight novel diagnostic SNPs that specifically discriminate the different sub-groups of Danish strains were identified and developed into PCR-based genotyping assays.
URL: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0134699&type=printable
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/21667
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

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作者单位: University Paris-Est, Anses, Animal Health Laboratory, Maisons-Alfort, France;University Paris-Est, Anses, Animal Health Laboratory, Maisons-Alfort, France;National Veterinary Institute, Technical University of Denmark, Frederiksberg, Denmark;National Veterinary Institute, Technical University of Denmark, Frederiksberg, Denmark

Recommended Citation:
Sylviane Derzelle,Guillaume Girault,Branko Kokotovic,et al. Whole Genome-Sequencing and Phylogenetic Analysis of a Historical Collection of Bacillus anthracis Strains from Danish Cattle[J]. PLOS ONE,2015-01-01,10(8)
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