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DOI: 10.1371/journal.pone.0136374
论文题名:
The Prognostic Value of Forkhead Box P3 Expression in Operable Breast Cancer: A Large-Scale Meta-Analysis
作者: Shu Chen Lin; Zhi Hua Gan; Yang Yao; Da Liu Min
刊名: PLOS ONE
ISSN: 1932-6203
出版年: 2015
发表日期: 2015-8-25
卷: 10, 期:8
语种: 英语
英文关键词: Regulatory T cells ; Meta-analysis ; Lymphocytes ; Breast cancer ; T cells ; Metastasis ; Regional geography ; Histology
英文摘要: Background Recent studies have shown that the forkhead box P3 (FOXP3) protein has a prognostic role in breast cancer. However, these results are controversial. Therefore, the aim of this meta-analysis was to clarify the prognostic role of FOXP3 expression in operable breast cancer cases. Methods Eligible studies describing the use of FOXP3 as a prognostic factor for operable breast cancer cases were identified. Clinicopathological features, disease-free survival (DFS), and overall survival (OS) data were collected from these studies and were analyzed using Stata software. Results A total of 16 articles containing data from 13,217 breast cancer patients met the inclusion criteria established for this study. The subsequent meta-analysis that was performed showed that high levels of FOXP3 are not significantly associated with DFS and OS with significant heterogeneity. An additional subgroup analysis demonstrated that intratumoral FOXP3+ regulatory T cells (Tregs) were positively correlated with adverse clinicopathological parameters, yet they did not show an association with DFS or OS. For tumor cells, the pooled results revealed that FOXP3 is significantly associated with DFS (HR: 2.55, 95% CI: 1.23–5.30) but is not associated with clinicopathological parameters or OS. We also observed a significant correlation between FOXP3 expression and survival in the estrogen receptor-positive (ER)+ subgroup (HR: 1.83, 95% CI: 1.36–2.47 for DFS, HR: 1.87, 95% CI 1.28–2.73 for OS), in the Asian region (HR: 1.98, 95% CI: 1.56–2.50 for DFS, HR: 1.93, 95% CI: 1.12–3.35 for OS) and using the median as the FOXP3-positive cut-off value (HR: 1.94, 95% CI: 1.57–2.39 for DFS, HR: 2.06; 95% CI: 1.36–3.11 for OS). Conclusion This meta-analysis indicates that a prognostic role for FOXP3 expression in operable breast cancer cases depends on the FOXP3-positive region, ER status, geographic region and the FOXP3-positive cut-off value.
URL: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0136374&type=printable
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/21668
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

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作者单位: Department of Oncology, Shanghai Sixth People’s Hospital East Campus, Shanghai Jiao Tong University, Shanghai, People’s Republic of China;Department of Oncology, Shanghai Sixth People’s Hospital East Campus, Shanghai Jiao Tong University, Shanghai, People’s Republic of China;Department of Oncology, The Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China;Department of Oncology, Shanghai Sixth People’s Hospital East Campus, Shanghai Jiao Tong University, Shanghai, People’s Republic of China

Recommended Citation:
Shu Chen Lin,Zhi Hua Gan,Yang Yao,et al. The Prognostic Value of Forkhead Box P3 Expression in Operable Breast Cancer: A Large-Scale Meta-Analysis[J]. PLOS ONE,2015-01-01,10(8)
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