globalchange  > 过去全球变化的重建
DOI: 10.1371/journal.pone.0129272
论文题名:
Transmission and Demographic Dynamics of Coxsackievirus B1
作者: Pei-Yu Chu; Yu-Chang Tyan; Yao-Shen Chen; Hsiu-Lin Chen; Po-Liang Lu; Yu-Hsien Chen; Bao-Chen Chen; Tsi-Shu Huang; Chu-Feng Wang; Hui-Ju Su; Yong-Ying Shi; Bintou Sanno-Duanda; Kuei-Hsiang Lin; Kazushi Motomura
刊名: PLOS ONE
ISSN: 1932-6203
出版年: 2015
发表日期: 2015-6-8
卷: 10, 期:6
语种: 英语
英文关键词: Phylogenetic analysis ; Taiwan ; Phylogenetics ; Coxsackieviruses ; Phylogeography ; Computer software ; Sequence analysis ; Enterovirus infection
英文摘要: The infectious activity of coxsackievirus B1 (CV-B1) in Taiwan was high from 2008 to 2010, following an alarming increase in severe neonate disease in the United States (US). To examine the relationship between CV-B1 strains isolated in Taiwan and those from other parts of the world, we performed a phylodynamic study using VP1 and partial 3Dpol (414 nt) sequences from 22 strains of CV-B1 isolated in Taiwan (1989–2010) and compared them to sequences from strains isolated worldwide. Phylogenetic trees were constructed by neighbor-joining, maximum likelihood, and Bayesian Monte Carlo Markov Chain methods. Four genotypes (GI–IV) in the VP1 region of CV-B1 and three genotypes (GA–C) in the 3Dpol region of enterovirus B were identified and had high support values. The phylogenetic analysis indicates that the GI and GIII strains in VP1 were geographically distributed in Taiwan (1993–1994) and in India (2007–2009). On the other hand, the GII and GIV strains appear to have a wider spatiotemporal distribution and ladder-like topology A stair-like phylogeny was observed in the VP1 region indicating that the phylogeny of the virus may be affected by different selection pressures in the specified regions. Further, most of the GI and GII strains in the VP1 tree were clustered together in GA in the 3D tree, while the GIV strains diverged into GB and GC. Taken together, these data provide important insights into the population dynamics of CV-B1 and indicate that incongruencies in specific gene regions may contribute to spatiotemporal patterns of epidemicity for this virus.
URL: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0129272&type=printable
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/21684
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

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作者单位: Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC;Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC;Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan;Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan;National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center, Kaohsiung 804, Taiwan;Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 804, Taiwan;Division of Infectious Diseases, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC;Division of Microbiology, Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC;Department of Internal Medicine, National Yang-Ming Medical University, Taipei, Taiwan, ROC;Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC;Department of Laboratory Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan;Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC;Division of Microbiology, Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC;Division of Microbiology, Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC;Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC;Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC;Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC;Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC;Edward Francis Small Teaching Hospital, Banjul, Gambia;Department of Laboratory Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan;Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan;Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Research Institute of Microbial Diseases, Osaka University, Nonthaburi, Thailand

Recommended Citation:
Pei-Yu Chu,Yu-Chang Tyan,Yao-Shen Chen,et al. Transmission and Demographic Dynamics of Coxsackievirus B1[J]. PLOS ONE,2015-01-01,10(6)
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