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DOI:	10.1371/journal.pone.0138884
论文题名:	Occupational Exposure to Hydrazine and Subsequent Risk of Lung Cancer: 50-Year Follow-Up
作者:	Joan K. Morris; Nicholas J. Wald; Anna L. Springett
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2015
发表日期:	2015-9-22
卷:	10, 期:9
语种:	英语
英文关键词:	Lung and intrathoracic tumors ; Digestive system ; Death rates ; Coronary heart disease ; England ; Vapors ; Dissolved oxygen ; Secondary lung tumors
英文摘要:	Purpose Hydrazine is carcinogenic in animals, but there is inadequate evidence to determine if it is carcinogenic in humans. This study aimed to evaluate the association between hydrazine exposure and the risk of lung cancer. Methods The cause specific mortality rates of a cohort of 427 men who were employed at an English factory that produced hydrazine between 1945 and 1971 were compared with national mortality rates. Results By the end of December 2012 205 deaths had occurred. For men in the highest exposure category with greater than two years exposure and after more than ten years since first exposure the relative risks compared with national rates were: 0.85 (95% CI: 0.18–2.48) for lung cancer, 0.61 (95% CI: 0.07–2.21) for cancers of the digestive system, and 0.44 (95% CI: 0.05–1.57) for other cancers. Conclusions After 50 years of follow up, the results provide no evidence of an increased risk of death from lung cancer or death from any other cause.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0138884&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/22160
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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File Name/ File Size	Content Type	Version	Access	License
journal.pone.0138884.PDF（156KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Centre of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, United Kingdom;Centre of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, United Kingdom;Centre of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, United Kingdom

Recommended Citation:

Joan K. Morris,Nicholas J. Wald,Anna L. Springett. Occupational Exposure to Hydrazine and Subsequent Risk of Lung Cancer: 50-Year Follow-Up[J]. PLOS ONE,2015-01-01,10(9)

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