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DOI:	10.1371/journal.pone.0125540
论文题名:	Non-Invasive Acoustical sensing of Drug-Induced Effects on the Contractile Machinery of Human Cardiomyocyte Clusters
作者:	Angelika Kunze; Daniella Steel; Kerstin Dahlenborg; Peter Sartipy; Sofia Svedhem
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2015
发表日期:	2015-5-11
卷:	10, 期:5
语种:	英语
英文关键词:	Isoproterenol ; Acoustics ; Electrochemistry ; Acoustic signals ; Arrhythmia ; Cytoskeleton ; Muscle cells ; Quartz
英文摘要:	There is an urgent need for improved models for cardiotoxicity testing. Here we propose acoustic sensing applied to beating human cardiomyocyte clusters for non-invasive, surrogate measuring of the QT interval and other characteristics of the contractile machinery. In experiments with the acoustic method quartz crystal microbalance with dissipation monitoring (QCM-D), the shape of the recorded signals was very similar to the extracellular field potential detected in electrochemical experiments, and the expected changes of the QT interval in response to addition of conventional drugs (E-4031 or nifedipine) were observed. Additionally, changes in the dissipation signal upon addition of cytochalasin D were in good agreement with the known, corresponding shortening of the contraction-relaxation time. These findings suggest that QCM-D has great potential as a tool for cardiotoxicological screening, where effects of compounds on the cardiomyocyte contractile machinery can be detected independently of whether the extracellular field potential is altered or not.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0125540&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/22280
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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journal.pone.0125540.PDF（1489KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Department of Applied Physics, Chalmers University of Technology, Göteborg, Sweden;Cellectis AB, Göteborg, Sweden;Cellectis AB, Göteborg, Sweden;Cellectis AB, Göteborg, Sweden;Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden;Department of Applied Physics, Chalmers University of Technology, Göteborg, Sweden

Recommended Citation:

Angelika Kunze,Daniella Steel,Kerstin Dahlenborg,et al. Non-Invasive Acoustical sensing of Drug-Induced Effects on the Contractile Machinery of Human Cardiomyocyte Clusters[J]. PLOS ONE,2015-01-01,10(5)

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