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globalchange > 过去全球变化的重建

DOI:	10.1371/journal.pone.0163019
论文题名:	A Molecular Approach to the Sexing of the Triple Burial at the Upper Paleolithic Site of Dolní Věstonice
作者:	Alissa Mittnik; Chuan-Chao Wang; Jiří Svoboda; Johannes Krause
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2016
发表日期:	2016-10-5
卷:	11, 期:10
语种:	英语
英文关键词:	Shotgun sequencing ; Ancient DNA ; Chromosomes ; Sequence alignment ; Paleogenetics ; X chromosomes ; Sex chromosomes ; Y chromosomes
英文摘要:	In the past decades ancient DNA research has brought numerous insights to archaeological research where traditional approaches were limited. The determination of sex in human skeletal remains is often challenging for physical anthropologists when dealing with incomplete, juvenile or pathological specimens. Molecular approaches allow sexing on the basis of sex-specific markers or by calculating the ratio of DNA derived from different chromosomes. Here we propose a novel approach that relies on the ratio of X chromosome-derived shotgun sequencing data to the autosomal coverage, thus establishing the probability of an XX or XY karyotype. Applying this approach to the individuals of the Upper Paleolithic triple burial of Dolní Věstonice reveals that all three skeletons, including the individual DV 15, whose sex has long been debated due to a pathological condition, were male.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0163019&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/23295
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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journal.pone.0163019.PDF（1986KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View 联系获取全文

作者单位:

Max Planck Institute for the Science of Human History, D-07745, Jena, Germany;Institute for Archeological Sciences, University of Tübingen, D-72070, Tübingen, Germany;Institute for Archeological Sciences, University of Tübingen, D-72070, Tübingen, Germany;Department of Genetics, Harvard Medical School, Boston, Massachusetts, 02115, United States of America;Department of Anthropology, Faculty of Science, Masaryk University, Kotlářská, 61137, Brno, Czech Republic;Institute of Archaeology, Academy of Science of the Czech Republic, 69129, Dolní Věstonice, Czech Republic;Max Planck Institute for the Science of Human History, D-07745, Jena, Germany;Institute for Archeological Sciences, University of Tübingen, D-72070, Tübingen, Germany

Recommended Citation:

Alissa Mittnik,Chuan-Chao Wang,Jiří Svoboda,et al. A Molecular Approach to the Sexing of the Triple Burial at the Upper Paleolithic Site of Dolní Věstonice[J]. PLOS ONE,2016-01-01,11(10)

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