globalchange  > 过去全球变化的重建
DOI: 10.1371/journal.pone.0155691
论文题名:
The Lake Chad Basin, an Isolated and Persistent Reservoir of Vibrio cholerae O1: A Genomic Insight into the Outbreak in Cameroon, 2010
作者: Rolf S. Kaas; Antoinette Ngandjio; Ariane Nzouankeu; Achiraya Siriphap; Marie-Christine Fonkoua; Frank M. Aarestrup; Rene S. Hendriksen
刊名: PLOS ONE
ISSN: 1932-6203
出版年: 2016
发表日期: 2016-5-18
卷: 11, 期:5
语种: 英语
英文关键词: Vibrio cholerae ; Cholera ; Lakes ; Chad ; Antimicrobial resistance ; El Tor ; Cameroon ; Phylogenetics
英文摘要: The prevalence of reported cholera was relatively low around the Lake Chad basin until 1991. Since then, cholera outbreaks have been reported every couple of years. The objective of this study was to investigate the 2010/2011 Vibrio cholerae outbreak in Cameroon to gain insight into the genomic make-up of the V. cholerae strains responsible for the outbreak. Twenty-four strains were isolated and whole genome sequenced. Known virulence genes, resistance genes and integrating conjugative element (ICE) elements were identified and annotated. A global phylogeny (378 genomes) was inferred using a single nucleotide polymorphism (SNP) analysis. The Cameroon outbreak was found to be clonal and clustered distant from the other African strains. In addition, a subset of the strains contained a deletion that was found in the ICE element causing less resistance. These results suggest that V. cholerae is endemic in the Lake Chad basin and different from other African strains.
URL: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155691&type=printable
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/23325
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

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作者单位: National Food Institute, Technical University of Denmark, Research Group for Genomic Epidemiology, WHO Collaborating Center for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kgs. Lyngby, Denmark;Centre Pasteur du Cameroon, Service Hygiène et Environnement section Microbiologie, P.O. Box 1274, Yaoundé, Cameroon;Centre Pasteur du Cameroon, Laboratory of Bacteriology, P.O. Box 1274, Yaoundé, Cameroon;Department of Microbiology and Parasitology, Faculty of Medical Science, University of Phayao, Phayao, 56000, Thailand;Department of Microbiology, Faculty of Public Health, Mahidol University, Bangkok, 10400, Thailand;Centre Pasteur du Cameroon, Laboratory of Bacteriology, P.O. Box 1274, Yaoundé, Cameroon;National Food Institute, Technical University of Denmark, Research Group for Genomic Epidemiology, WHO Collaborating Center for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kgs. Lyngby, Denmark;National Food Institute, Technical University of Denmark, Research Group for Genomic Epidemiology, WHO Collaborating Center for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kgs. Lyngby, Denmark

Recommended Citation:
Rolf S. Kaas,Antoinette Ngandjio,Ariane Nzouankeu,et al. The Lake Chad Basin, an Isolated and Persistent Reservoir of Vibrio cholerae O1: A Genomic Insight into the Outbreak in Cameroon, 2010[J]. PLOS ONE,2016-01-01,11(5)
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