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DOI:	10.1371/journal.pone.0167101
论文题名:	Highly Divergent Clostridium difficile Strains Isolated from the Environment
作者:	Sandra Janezic; Mojca Potocnik; Valerija Zidaric; Maja Rupnik
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2016
发表日期:	2016-11-23
卷:	11, 期:11
语种:	英语
英文关键词:	Clostridium difficile ; Polymerase chain reaction ; Surface water ; Sequence databases ; Antimicrobial resistance ; Antimicrobials ; Sequence analysis ; Toxins
英文摘要:	Clostridium difficile is one of the most important human and animal pathogens. However, the bacterium is ubiquitous and can be isolated from various sources. Here we report the prevalence and characterization of C. difficile in less studied environmental samples, puddle water (n = 104) and soil (n = 79). C. difficile was detected in 14.4% of puddle water and in 36.7% of soil samples. Environmental strains displayed antimicrobial resistance patterns comparable to already published data of human and animal isolates. A total of 480 isolates were grouped into 34 different PCR ribotypes. More than half of these (52.9%; 18 of 34) were already described in humans or animals. However, 14 PCR ribotypes were new in our PCR ribotype library and all but one were non-toxigenic. The multilocus sequence analysis of these new PCR ribotypes revealed that non-toxigenic environmental isolates are phylogenetically distinct and belong to three highly divergent clades, two of which have not been described before. Our data suggest that environment is a potential reservoir of genetically diverse population of C. difficile.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0167101&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/23427
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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File Name/ File Size	Content Type	Version	Access	License
journal.pone.0167101.pdf（1156KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

National Laboratory for Health, Environment and Food (NLZOH), Maribor, Slovenia;University of Maribor, Faculty of Medicine, Maribor, Slovenia;National Laboratory for Health, Environment and Food (NLZOH), Maribor, Slovenia;National Laboratory for Health, Environment and Food (NLZOH), Maribor, Slovenia;National Laboratory for Health, Environment and Food (NLZOH), Maribor, Slovenia;University of Maribor, Faculty of Medicine, Maribor, Slovenia

Recommended Citation:

Sandra Janezic,Mojca Potocnik,Valerija Zidaric,et al. Highly Divergent Clostridium difficile Strains Isolated from the Environment[J]. PLOS ONE,2016-01-01,11(11)

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