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DOI: 10.1371/journal.pone.0162370
论文题名:
An Intronic Polymorphism in couch potato Is Not Distributed Clinally in European Drosophila melanogaster Populations nor Does It Affect Diapause Inducibility
作者: Valeria Zonato; Giorgio Fedele; Charalambos P. Kyriacou
刊名: PLOS ONE
ISSN: 1932-6203
出版年: 2016
发表日期: 2016-9-6
卷: 11, 期:9
语种: 英语
英文关键词: Diapause ; Latitude ; Drosophila melanogaster ; Europe ; Linkage disequilibrium ; Drosophila ; North America ; Italy
英文摘要: couch potato (cpo) encodes an RNA binding protein that has been reported to be expressed in the peripheral and central nervous system of embryos, larvae and adults, including the major endocrine organ, the ring gland. A polymorphism in the D. melanogaster cpo gene coding region displays a latitudinal cline in frequency in North American populations, but as cpo lies within the inversion In(3R)Payne, which is at high frequencies and itself shows a strong cline on this continent, interpretation of the cpo cline is not straightforward. A second downstream SNP in strong linkage disequilibrium with the first has been claimed to be primarily responsible for the latitudinal cline in diapause incidence in USA populations.Here, we investigate the frequencies of these two cpo SNPs in populations of Drosophila throughout continental Europe. The advantage of studying cpo variation in Europe is the very low frequency of In(3R)Payne, which we reveal here, does not appear to be clinally distributed. We observe a very different geographical scenario for cpo variation from the one in North America, suggesting that the downstream SNP does not play a role in diapause. In an attempt to verify whether the SNPs influence diapause we subsequently generated lines with different combinations of the two cpo SNPs on known timeless (tim) genetic backgrounds, because polymorphism in the clock gene tim plays a significant role in diapause inducibility. Our results reveal that the downstream cpo SNP does not seem to play any role in diapause induction in European populations in contrast to the upstream coding cpo SNP. Consequently, all future diapause studies on strains of D. melanogaster should initially determine their tim and cpo status.
URL: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0162370&type=printable
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/23512
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

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作者单位: Department of Genetics, University of Leicester, Leicester, LE1 7RH, United Kingdom;Department of Genetics, University of Leicester, Leicester, LE1 7RH, United Kingdom;Department of Genetics, University of Leicester, Leicester, LE1 7RH, United Kingdom

Recommended Citation:
Valeria Zonato,Giorgio Fedele,Charalambos P. Kyriacou. An Intronic Polymorphism in couch potato Is Not Distributed Clinally in European Drosophila melanogaster Populations nor Does It Affect Diapause Inducibility[J]. PLOS ONE,2016-01-01,11(9)
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